Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) that exhibits strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC 50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 ranging from 0.018 to 0.025 nM). Additionally, Azvudine hydrochloride effectively inhibits NRTI-resistant viral strains.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 142.00 | |
5 mg | 5 days | $ 247.00 | |
10 mg | 5 days | $ 397.00 |
Description | Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) that exhibits strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC 50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC 50 ranging from 0.018 to 0.025 nM). Additionally, Azvudine hydrochloride effectively inhibits NRTI-resistant viral strains. |
Targets&IC50 | HIV-2:0.018-0.02 nM (EC50), HIV-1:0.03-6.92 nM (EC50) |
In vitro | Azvudine (RO-0622) hydrochloride effectively inhibits both the wild-type HIV-1 IIIB and HIV-1 RF strains, with EC50 values ranging between 30 to 110 pM. It also demonstrates potent activity against various other HIV-1 strains, including KM018, TC-1, and WAN T69N, with respective EC50 values of 6.92, 0.34, and 0.45 nM. Importantly, Azvudine is active against strains resistant to nucleoside reverse transcriptase inhibitors (NRTIs), such as HIV-1 74V, protease inhibitors (PIs) including HIV-1 L10R/M46I/L63P/V82T/I84V and HIV-1 RF V82F/184V, and fusion inhibitors (FIs), specifically the strain pNL4-3 gp41 (36G) V38A/N42T. Against these resistant strains, Azvudine hydrochloride shows EC50 values of 0.11, 0.14, 0.37, and 0.36 nM, respectively[1]. |
Synonyms | RO-0622 hydrochloride, Azvudine hydrochloride, FNChydrochloride |
Molecular Weight | 322.68 |
Formula | C9H12ClFN6O4 |
CAS No. | 1333126-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Azvudine hydrochloride 1333126-31-0 RO-0622 Hydrochloride RO-0622 hydrochloride RO 0622 Hydrochloride RO0622 Hydrochloride FNChydrochloride Azvudine Hydrochloride inhibitor inhibit