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Azvudine hydrochloride

Name: Azvudine hydrochloride
Brand: TargetMol
SKU: T38727
Price: 699 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38727Cas No. 1333126-31-0

Alias RO-0622 hydrochloride, FNC hydrochloride

Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) with strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC50 ranging from 0.018 to 0.025 nM), and effectively inhibits NRTI-resistant viral strains.

Azvudine hydrochloride

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Purity: 99.06%

Catalog No. T38727Alias RO-0622 hydrochloride, FNC hydrochlorideCas No. 1333126-31-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$699	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.06%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Azvudine hydrochloride (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI) with strong antiviral effects against HIV, HBV, and HCV. It demonstrates highly potent inhibition of HIV-1 (EC50 ranging from 0.03 to 6.92 nM) and HIV-2 (EC50 ranging from 0.018 to 0.025 nM), and effectively inhibits NRTI-resistant viral strains.
Targets&IC50	HIV-1:0.03-6.92 nM (EC50), HIV-2:0.018-0.02 nM (EC50)
In vitro	Azvudine hydrochloride exhibits potent inhibitory effects against HIV-1 (EC50 = 0.03-6.92 nM) and HIV-2 (EC50 = 0.018-0.025 nM). When used in combination with six approved anti-HIV drugs in C8166 and PBMC cells, it also demonstrates synergistic effects[1].
Synonyms	RO-0622 hydrochloride, FNC hydrochloride

Chemical Properties

Molecular Weight	322.68
Formula	C₉H₁₂ClFN₆O₄
Cas No.	1333126-31-0
Smiles	Cl.Nc1ccn([C@@H]2O[C@@](CO)(N=[N+]=[N-])[C@@H](O)[C@@H]2F)c(=O)n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (309.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0990 mL	15.4952 mL	30.9905 mL	154.9523 mL
5 mM	0.6198 mL	3.0990 mL	6.1981 mL	30.9905 mL
10 mM	0.3099 mL	1.5495 mL	3.0990 mL	15.4952 mL
20 mM	0.1550 mL	0.7748 mL	1.5495 mL	7.7476 mL
50 mM	0.0620 mL	0.3099 mL	0.6198 mL	3.0990 mL
100 mM	0.0310 mL	0.1550 mL	0.3099 mL	1.5495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc