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SMBA1
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Catalog No. T8792Cas No. 906440-37-7
SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer.
SMBA1
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Purity: 99.2%
Catalog No. T8792Cas No. 906440-37-7
SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $238 | - | In Stock | |
| 10 mg | $349 | - | In Stock | |
| 25 mg | $568 | - | In Stock | |
| 50 mg | $793 | - | In Stock | |
| 100 mg | $1,090 | - | In Stock | |
| 500 mg | $2,190 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.2%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer. |
| Targets&IC50 | Bax:43.3 nM (Ki) |
| In vitro | SMBA1 exhibited Bax agonist activity by inhibiting the phosphorylation of S184, promoting the insertion of Bax into the mitochondrial membrane and the formation of Bax oligomers, and thereby inducing conformational changes in Bax. SMBA1 (0, 0.1, 1, 5, 10 µM; 24 hr) potentiated Bax expression in a dose-dependent manner in A549 cells. [1] |
| In vivo | SMBA1 (2, 10, 40, 60 mg/kg; intraperitoneal injection; once daily for 10 days) exhibited antitumor activity in mice. [1] |
| Molecular Weight | 315.32 |
| Formula | C20H13NO3 |
| Cas No. | 906440-37-7 |
| Smiles | O=[N+]([O-])C1=CC2=C(C3=CC=CC=C3C2=CC4=C(O)C=CC=C4)C=C1 |
| Relative Density. | 1.392 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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