ATR Protein, Human, Recombinant (GST)

Name: ATR Protein, Human, Recombinant (GST)
Brand: TargetMol
SKU: TMPC-00055
Rating: 4.5 (1 reviews)

(Synonyms: Serine/threonine-protein kinase ATR, FRP1, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein) Copy Product Info

Synonyms: Serine/threonine-protein kinase ATR, FRP1, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein

Catalog No. TMPC-00055 Copy Product Info

ATR Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q13535.

Pack Size	Price	USA Stock	Global Stock	Quantity
20 μg	$987	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
Description	ATR Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q13535.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	Q13535
Construction	Recombinant human ATR (2245-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>70% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Synonyms	Serine/threonine-protein kinase ATR, FRP1, FRAP-related protein 1, ATR, Ataxia telangiectasia and Rad3-related protein
Research Background	ATR is a serine/threonine protein kinase and ATR kinase inhibitors potentiate chemotherapy and radiation. The ATR kinase inhibitor VX-970 (NSC 780162) is in clinical development in combination with primary cytotoxic agents and as a monotherapy for tumors harboring specific mutations. Nucleotide excision repair (NER) is the sole mechanism of UV-induced DNA lesion repair in mammals. A single round of NER requires multiple components including seven core NER factors, xeroderma pigmentosum A-G (XPA-XPG), and many auxiliary effector proteins including ATR serine/threonine kinase. The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2 (CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase (ATR)/CHEK1 (best known as CHK1) cascades are the 2 major signaling pathways driving the DNA damage response (DDR), a network of processes crucial for the preservation of genomic stability that act as a barrier against tumorigenesis and tumor progression.

Chemical Properties

Molecular Weight

~70 kDa

Storage & Solubility Information

Storage

Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: ATR Protein, Human, Recombinant (GST) chemical structure | ATR Protein, Human, Recombinant (GST) molecular weight