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Anti-PMAIP1 Antibody (1B633) is a Rabbit antibody targeting PMAIP1. Anti-PMAIP1 Antibody (1B633) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
| Description | Anti-PMAIP1 Antibody (1B633) is a Rabbit antibody targeting PMAIP1. Anti-PMAIP1 Antibody (1B633) can be used in WB. |
| Ig Type | IgG |
| Clone | 1B633 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion. |
| Tissue Specificity | Highly expressed in adult T-cell leukemia cell line. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Noxa is a pro-apoptotic Bcl-2 family protein that contains a single Bcl-2 homology (BH3) domain. Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. |
| Immunogen | A synthesized peptide: human PMAIP1 |
| Antigen Species | Human |
| Gene Name | PMAIP1 |
| Gene ID | |
| Protein Name | Phorbol-12-myristate-13-acetate-induced protein 1 |
| Uniprot ID | |
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
| Molecular Weight | Theoretical: 6 kDa. Actual: 16 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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