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JNJ-54175446

Name: JNJ-54175446
Brand: TargetMol
SKU: T15622
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15622Cas No. 1627902-21-9

Alias JNJ-5446

JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.

JNJ-54175446

🥰Excellent

Purity: 99.79%

Catalog No. T15622Alias JNJ-5446Cas No. 1627902-21-9

JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$293	In Stock	In Stock
5 mg	$722	In Stock	In Stock
10 mg	$987	In Stock	In Stock
25 mg	$1,520	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,760	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.79%

ee:99.492%

Resource Download

COA CSFC FNMR HNMR ORP LCMS

Product Introduction

Bioactivity

Description	JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.
Targets&IC50	P2X7 receptor (rat):8.81(pic50), P2X7 receptor (human):(pic50)8.46 , P2X7 receptor (rat):8.81 (pIC50), P2X7 receptor (human):8.46 (pIC50)
In vitro	JNJ-54175446 is a selective purinergic P2X7 receptor (P2X7R) antagonist that attenuates the release of IL-1β/IL-18 from microglial cells[1].
In vivo	JNJ-54175446 (30 mg/kg, intraperitoneal) administered once daily significantly reduces spontaneous recurrent seizures in mice, persisting for several days after the end of treatment[1].
Synonyms	JNJ-5446

Chemical Properties

Molecular Weight	440.78
Formula	C₁₈H₁₃ClF₄N₆O
Cas No.	1627902-21-9
Smiles	C[C@H]1N(CCc2c1nnn2-c1ncc(F)cn1)C(=O)c1cccc(c1Cl)C(F)(F)F
Relative Density.	1.62 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (113.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2687 mL	11.3435 mL	22.6871 mL	113.4353 mL
5 mM	0.4537 mL	2.2687 mL	4.5374 mL	22.6871 mL
10 mM	0.2269 mL	1.1344 mL	2.2687 mL	11.3435 mL
20 mM	0.1134 mL	0.5672 mL	1.1344 mL	5.6718 mL
50 mM	0.0454 mL	0.2269 mL	0.4537 mL	2.2687 mL
100 mM	0.0227 mL	0.1134 mL	0.2269 mL	1.1344 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc