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NS-3-008 hydrochloride

🥰Excellent
Catalog No. T8494Cas No. 1172854-54-4
Alias NS-3-008 HCl

NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).

NS-3-008 hydrochloride

NS-3-008 hydrochloride

🥰Excellent
Purity: 99.56%
Catalog No. T8494Alias NS-3-008 HClCas No. 1172854-54-4
NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$38In StockIn Stock
10 mg$58In StockIn Stock
25 mg$106In StockIn Stock
50 mg$178In StockIn Stock
100 mg$266In StockIn Stock
200 mg$392-In Stock
1 mL x 10 mM (in DMSO)$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.56%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).
Targets&IC50
G0s2:2.25 μM
In vivo
Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?In contrast, administration of NS-3-008 did not affect the MBP in wild-type sham and 5/6Nx mice.?NS-3-008 as a novel G0s2 inhibitor and showed that administration of this inhibitor ameliorated renal dysfunction in wild-type 5/6Nx mice.
SynonymsNS-3-008 HCl
Chemical Properties
Molecular Weight269.81
FormulaC14H24ClN3
Cas No.1172854-54-4
SmilesCl.CCCCCCNC(=N)NCc1ccccc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (444.76 mM), Sonication is recommended.
H2O: 125 mg/mL (463.29 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.83 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.7063 mL18.5316 mL37.0631 mL185.3156 mL
5 mM0.7413 mL3.7063 mL7.4126 mL37.0631 mL
10 mM0.3706 mL1.8532 mL3.7063 mL18.5316 mL
20 mM0.1853 mL0.9266 mL1.8532 mL9.2658 mL
50 mM0.0741 mL0.3706 mL0.7413 mL3.7063 mL
100 mM0.0371 mL0.1853 mL0.3706 mL1.8532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

transcriptionalStat5renalp65NS-3-008 HydrochlorideNS3008 hydrochlorideNS 3 008 hydrochlorideInhibitorinhibitHsd17b4G0s2dysfunctionCKDCcl2ameliorate
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