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Razuprotafib

Name: Razuprotafib
Brand: TargetMol
SKU: T16724
Price: 253 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16724Cas No. 1008510-37-9

Alias AKB-9778

Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.

Razuprotafib

🥰Excellent

Purity: 99.76%

Catalog No. T16724Alias AKB-9778Cas No. 1008510-37-9

Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.

Pack Size	Price	Availability
1 mg	$253	In Stock
5 mg	$413	In Stock
10 mg	$619	In Stock
25 mg	$1,050	In Stock
50 mg	$1,370	In Stock
100 mg	$1,790	In Stock
1 mL x 10 mM (in DMSO)	$533	In Stock

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Purity:99.76%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.
Targets&IC50	HPTPß:50 nM
In vitro	Razuprotafib inhibits the phosphatase activity of VE-PTP with an IC50 of 17 pM. Razuprotafib inhibits the phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib inhibits HPTPη (IC50 = 36 pM) . Razuprotafib inhibits HPTPγ (IC50 = 100 pM). Razuprotafib 0.17 to 50 μM HUVEC 10 minutes in WB concentration-dependent phosphorylation of TIE2 and downstream components of the TIE2 signaling pathway, including eNOS, AKT, and ERK.
In vivo	Rho-VEGF–transgenic mice s.c. injection 20 mg/kg 12 hours promotes phosphorylation of TIE2 in retinal endothelial cells Rho-VEGF mice s.c. injection 10-20 mg/kg twice daily for 7 days suppresses subretinal neovascularization.
Synonyms	AKB-9778

Chemical Properties

Molecular Weight	586.7
Formula	C₂₆H₂₆N₄O₆S₃
Cas No.	1008510-37-9
Smiles	COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1cccs1
Relative Density.	1.450 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (170.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7044 mL	8.5222 mL	17.0445 mL	85.2224 mL
5 mM	0.3409 mL	1.7044 mL	3.4089 mL	17.0445 mL
10 mM	0.1704 mL	0.8522 mL	1.7044 mL	8.5222 mL
20 mM	0.0852 mL	0.4261 mL	0.8522 mL	4.2611 mL
50 mM	0.0341 mL	0.1704 mL	0.3409 mL	1.7044 mL
100 mM	0.0170 mL	0.0852 mL	0.1704 mL	0.8522 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc