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Vardenafil-d5 hydrochloride
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Catalog No. TMID-0801
Vardenafil-d5hydrochloride is the deuterium-labeled version of Vardenafil hydrochloride. Vardenafil dihydrochloride is a highly selective and orally active phosphodiesterase 5 (PDE5) inhibitor, with an IC50 of 0.7 nM. It displays IC50 values of 180 nM and 11 nM for PDE1 and PDE6, respectively, while for PDE3 and PDE4, the IC50 is greater than 1000 nM. This compound non-competitively inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP), leading to increased cGMP levels. Vardenafil dihydrochloride is useful for studying conditions such as erectile dysfunction, hepatitis, and diabetes.
Vardenafil-d5 hydrochloride
Vardenafil-d5 hydrochloride
😃Good
Catalog No. TMID-0801
Vardenafil-d5hydrochloride is the deuterium-labeled version of Vardenafil hydrochloride. Vardenafil dihydrochloride is a highly selective and orally active phosphodiesterase 5 (PDE5) inhibitor, with an IC50 of 0.7 nM. It displays IC50 values of 180 nM and 11 nM for PDE1 and PDE6, respectively, while for PDE3 and PDE4, the IC50 is greater than 1000 nM. This compound non-competitively inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP), leading to increased cGMP levels. Vardenafil dihydrochloride is useful for studying conditions such as erectile dysfunction, hepatitis, and diabetes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Vardenafil-d5hydrochloride is the deuterium-labeled version of Vardenafil hydrochloride. Vardenafil dihydrochloride is a highly selective and orally active phosphodiesterase 5 (PDE5) inhibitor, with an IC50 of 0.7 nM. It displays IC50 values of 180 nM and 11 nM for PDE1 and PDE6, respectively, while for PDE3 and PDE4, the IC50 is greater than 1000 nM. This compound non-competitively inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP), leading to increased cGMP levels. Vardenafil dihydrochloride is useful for studying conditions such as erectile dysfunction, hepatitis, and diabetes. |
| In vivo | Vardenafil hydrochloride (IV; 0.03 mg/kg) enhances recovery in rats with cavernous nerve injury. Additionally, vardenafil hydrochloride (IV; 0.17 mg/kg, once daily for 7 days) offers hepatic protection against Con A-induced hepatitis and reduces NF- levels in liver tissue. Furthermore, vardenafil hydrochloride (oral; 10 mg/kg, once daily for 25 weeks) prevents the reduction of tissue cGMP levels and inhibits the increase of 3-NT production in ZDF hearts. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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