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Ac4ManNAz

Name: Ac4ManNAz
Brand: TargetMol
SKU: T14093
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14093Cas No. 361154-30-5

Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.

Ac4ManNAz

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Purity: 98.42%

Catalog No. T14093Cas No. 361154-30-5

Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$178	In Stock	In Stock
50 mg	$268	In Stock	In Stock
100 mg	$397	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.42%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.

In vitro

METHODS: A549 cells were cultured with 0, 10, and 50 μM Ac4ManNAz, and total RNA was extracted to evaluate the quantity and quality of total RNA.
RESULTS Compared with untreated A549 cells, mRNA expression levels changed 7-fold; biological functional pathways related to urogenital cancer and cell invasion were significantly activated, while signal transduction related to cell maturation and surface receptor ligation was inhibited. [1]
METHODS: Ac4MAnNAz (0-50 μM) treated A549 cells, and analyzed the channel activation, proliferation ability and vitality of A549 cells treated with Ac4ManNAz; Ac4ManNAz (0, 10, 20, 50 μM, 30 hours) treated A549 cells, and performed wounds on A549 cells Healing and invasion assays.
RESULTS There was no significant change in the activities of TRP M7 and VSOR Cl channels, and the growth rate of A549 cells was reduced by 10%; as the concentration of Ac4ManNAz increased, the migration and invasion abilities gradually decreased, [1]

Chemical Properties

Molecular Weight	430.37
Formula	C₁₆H₂₂N₄O₁₀
Cas No.	361154-30-5
Smiles	O(C(C)=O)[C@@H]1[C@H](NC(CN=[N+]=[N-])=O)C(OC(C)=O)O[C@H](COC(C)=O)[C@H]1OC(C)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (586.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3236 mL	11.6179 mL	23.2358 mL	116.1791 mL
5 mM	0.4647 mL	2.3236 mL	4.6472 mL	23.2358 mL
10 mM	0.2324 mL	1.1618 mL	2.3236 mL	11.6179 mL
20 mM	0.1162 mL	0.5809 mL	1.1618 mL	5.8090 mL
50 mM	0.0465 mL	0.2324 mL	0.4647 mL	2.3236 mL
100 mM	0.0232 mL	0.1162 mL	0.2324 mL	1.1618 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc