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4F 4PP oxalate

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Catalog No. T22514Cas No. 144734-36-1

4F 4PP oxalate is a 5-HT2A antagonist.

4F 4PP oxalate

4F 4PP oxalate

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Purity: 97.34%
Catalog No. T22514Cas No. 144734-36-1
4F 4PP oxalate is a 5-HT2A antagonist.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$51In StockIn Stock
25 mg$93In StockIn Stock
50 mg$155In StockIn Stock
100 mg$230In StockIn Stock
200 mg$328In StockIn Stock
1 mL x 10 mM (in DMSO)$30In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.34%
Appearance:Solid
Color:White
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Product Introduction

4F 4PP oxalate AI Summary
4F 4PP oxalate exhibits binding affinity with a Ki of 5.3 nM against the 5-hydroxytryptamine 2 (5-HT2) receptor in rats using [3H]ketanserin as a radioligand and a Ki of 620.0 nM against the 5-hydroxytryptamine 1C (5-HT1C) receptor using [3H]mesulergine as a radioligand. It demonstrates selectivity for the 5-HT1C receptor over the 5-HT2 receptor, with a selectivity ratio of 120.0. Additionally, 4F 4PP oxalate has demonstrated antiviral activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours, with an inhibition rate of -0.56%. It also inhibits the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, achieving a 12.57% inhibition rate. Furthermore, the compound shows activity in VERO-6 cells, inhibiting SARS-CoV-2 induced cytotoxicity at 10 µM after 48 hours of exposure to 0.01 MOI virus, with an observed inhibition of -0.19%..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
4F 4PP oxalate is a 5-HT2A antagonist.
Targets&IC50
5-HT2A receptor:5.3 nM (Ki), 5-HT2C receptor:620 nM (Ki)
Chemical Properties
Molecular Weight429.49
FormulaC22H26FNO·C2H2O4
Cas No.144734-36-1
SmilesOC(=O)C(O)=O.Fc1ccc(cc1)C(=O)C1CCN(CCCCc2ccccc2)CC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 6.25 mg/mL (14.55 mM), Sonication is recommended.
Ethanol: 20 mM, Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.3283 mL11.6417 mL23.2834 mL116.4171 mL
5 mM0.4657 mL2.3283 mL4.6567 mL23.2834 mL
10 mM0.2328 mL1.1642 mL2.3283 mL11.6417 mL
Ethanol
1mg5mg10mg50mg
20 mM0.1164 mL0.5821 mL1.1642 mL5.8209 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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