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Anti-DIP13B Polyclonal Antibody
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Catalog No. TMAB-05165
Anti-DIP13B Polyclonal Antibody is a Rabbit antibody targeting DIP13B. Anti-DIP13B Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-DIP13B Polyclonal Antibody
Anti-DIP13B Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-05165
Anti-DIP13B Polyclonal Antibody is a Rabbit antibody targeting DIP13B. Anti-DIP13B Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Antigen Details
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| Description | Anti-DIP13B Polyclonal Antibody is a Rabbit antibody targeting DIP13B. Anti-DIP13B Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Chicken,Dog,Cow,Sheep) |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded (Rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (DCC interacting protein 13 beta; DIP13B) Polyclonal Antibody, Unconjugated (TMAB-05165) at 1: 200 overnight at 4°C, followed by a conjugated secondary antibody for 90 minutes. 2. Sample: Lovo Cell (Human) Lysate at 30 μg Primary: Anti-DIP13B (TMAB-05165) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 74 kD Observed band size: 76 kD 3. Sample: 293T Cell (Human) Lysate at 30 μg Primary: Anti-DIP13B (TMAB-05165) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 74 kD Observed band size: 76 kD |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. |
| Tissue Specificity | High levels in brain, heart, kidney and skeletal muscle. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The APPL family of proteins are involved in linking, trafficking and signaling downstream of tyrosine kinase receptors. APPL1, also designated adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; APPL; or DCC interacting protein 13å (DIP13å), and APPL2, also designated adaptor protein containing pH domain, PTB domain and leucine zipper motif 2 or DCC interacting protein 13∫ (DIP13∫), are involved in the coupling of epidermal growth factor (EGF) signaling and chromatin remodeling in the nucleus. They associate with GTPase Rab 5 and are released from the plasma membrane and translocated to the nucleus. In the nucleus, APPL1 and APPL2 associate with NuRD/MeCP1 and are essential for cell growth and proliferation. APPL2 also associates with follicle stimulating hormone receptor (FSHR). APPL2 is highly expressed in heart, brain, skeletal muscle, and kidney. APPL2 shares 54% homology with APPL1 |
| Immunogen | KLH conjugated synthetic peptide: human DIP13B/APPL2 |
| Antigen Species | Human |
| Gene Name | APPL2 |
| Gene ID | |
| Protein Name | DCC-interacting protein 13-beta |
| Uniprot ID | |
| Function | Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction. |
| Molecular Weight | Theoretical: 74 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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