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TargetMol | Tags Metabolism
ANGPTL
(4)
ATP Citrate Lyase
(15)
Acetyl-CoA Carboxylase
(32)
Aconitase
(2)
Acyltransferase
(145)
Adenosine Deaminase
(16)
AhR
(31)
Amino Acids and Derivatives
(1026)
Aminopeptidase
(70)
Amylase
(41)
Angiotensin-converting Enzyme (ACE)
(172)
Apolipoprotein
(9)
CETP
(17)
CPT
(5)
Calcium Channel
(628)
Carbonic Anhydrase
(215)
Casein Kinase
(159)
Cytochromes P450
(491)
DHFR
(58)
Decarboxylase
(7)
Dehydrogenase
(468)
Drug Metabolite
(587)
Endogenous Metabolite
(3224)
Epoxide Hydrolase
(57)
FAAH
(72)
FABP
(15)
FXR
(78)
Factor VIII
(6)
Factor VIIa
(5)
Factor Xa
(92)
Fatty Acid Synthase
(70)
GSNOR
(3)
Glucokinase
(71)
Glucosidase
(219)
Glutathione Peroxidase
(73)
Glyoxalase
(17)
HIF/HIF Prolyl-Hydroxylase
(194)
HMG-CoA Reductase
(69)
HSP
(264)
Hexokinase
(9)
Hydrogenase
(2)
Hydroxylase
(45)
IDO
(94)
Indoleamine 2,3-Dioxygenase (IDO)
(98)
Isocitrate Dehydrogenase (IDH)
(46)
LDL
(26)
LDLR
(14)
Lipase
(37)
Lipid
(44)
Liposome
(442)
Lipoxygenase
(194)
Liver X Receptor
(51)
MAGL
(61)
MAO
(108)
Mitochondrial Metabolism
(212)
N-Acetylglucosaminyltransferase
(1)
NADPH
(62)
NAMPT
(44)
NEDD4-1
(3)
NEDD8
(8)
NUDIX hydrolase
(2)
Neprilysin
(31)
PAI-1
(38)
PDE
(528)
PGK1
(3)
PKM
(43)
PPAR
(386)
Phosphatase
(432)
Phospholipase
(201)
Phosphorylase
(21)
Photosystem (PS)
(5)
Procollagen C Proteinase
(1)
Prolyl Endopeptidase (PREP)
(33)
RAR/RXR
(12)
REV-ERB
(9)
ROR
(96)
Reactive Oxygen Species
(773)
Reductase
(121)
Retinoid Receptor
(109)
SGK
(24)
Serine/threonin kinase
(90)
Stearoyl-CoA Desaturase (SCD)
(29)
Taste receptor
(6)
Thioredoxin
(2)
Transaminase
(3)
Transferase
(222)
Transketolase
(9)
UGT
(17)
Vitamin
(89)
Xanthine Oxidase
(73)
glycosidase
(28)
hCE
(2)
stilbene oxidase
(1)
transporter
(87)

Mitochondrial Metabolism

Mitochondrial metabolism encompasses pathways that generate ATP to drive intracellular unfavorable energetic reactions and produce the building blocks necessary for macromolecule synthesis.

MitoSOX Red
T753421003197-00-9In house
MitoSOX Red is a novel fluorescent probe that is specific and cell membrane-permeable and targets mitochondria in living cells.MitoSOX Red is oxidized by superoxide upon entry into the mitochondria and is not oxidized by other ROS or RNS-generating systems.MitoSOX Red then binds to nucleic acids in the mitochondrion and produces a strong red fluorescence.MitoSOX Red can be used as a fluorescent indicator for the specific detection of superoxide.MitoSOX Red can be used as a fluorescent indicator for the specific detection of superoxide. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. Superoxide dismutase (SOD) prevents the oxidation of MitoSOX Red.
  • $48
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TargetMol | Inhibitor Hot
Imeglimin hydrochloride
T7486775351-61-6
Imeglimin hydrochloride (EMD 387008 hydrochloride) is an oral hypoglycemic agent. Imeglimin improves insulin sensitivity, inhibits the production of reactive oxygen species, increases mitochondrial DNA, and improves mitochondrial function.
  • $35
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TargetMol | Inhibitor Hot
Mito-TEMPO
T194281334850-99-5
Mito-TEMPO, a mitochondria-targeted superoxide dismutase mimetic, scavenges superoxide and alkyl radicals, preventing mitochondrial oxidation, necrosis, and apoptosis.
  • $51
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TargetMol | Citations Cited
MPP+ iodide
T916936913-39-0
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
  • $30
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Rotenone
T297083-79-4
Rotenone is a natural plant-derived insecticide that acts as an inhibitor of mitochondrial electron transport chain complex I. It promotes the generation of mitochondrial reactive oxygen species, induces apoptosis, and is commonly used to establish Parkinson's disease models.
  • $42
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TargetMol | Citations Cited
Devimistat
T615795809-78-2
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potential chemopreventive and antineoplastic activities, and has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Advanced Cancer, and Pancreatic Cancer, among others.
  • $53
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FCCP
T6834370-86-5
FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer.
  • $34
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TargetMol | Citations Cited
(-)-Epigallocatechin Gallate
T2988989-51-5
(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.
  • $43
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TargetMol | Citations Cited
UK-5099
T444156396-35-1
UK-5099 (PF-1005023) is a specific and potent inhibitor of MPC carrier activity, effectively inhibiting pyruvate-dependent oxygen consumption in rat heart mitochondria with an IC50 of 50 nM [1].
  • $30
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IMT1
T88412304621-31-4
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
  • $74
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IACS-010759
T53371570496-34-2
IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.
  • $47
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MCU-i11
T9960902903-59-7
MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
  • $163
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Ciprofloxacin hydrochloride monohydrate
T813086393-32-0
Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic,is an antibiotic used to treat a number of bacterial infections
  • $41
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CCCP
T7081555-60-2
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
  • $41
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TargetMol | Citations Cited
Gboxin
T153732101315-36-8
Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.
  • $39
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Schaftoside
T389851938-32-0
Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
  • $35
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Perhexiline maleate
T124086724-53-4
Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2, reducing fatty acid metabolism, with IC50 values of 77 μM and 148 μM against rat heart and liver CPT1, respectively.
  • $37
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DX3-234
T640042941323-59-5
DX3-234 is a potent oxidative phosphorylation (OXPHOS) inhibitor that acts by inhibiting complex I in the mitochondrial electron transport chain (ETC), leading to intracellular ATP depletion and cell death, and can be used for the treatment of specific cancers dependent on aerobic metabolism, such as pancreatic cancer.
  • $293
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DX3-235
T641082749555-39-1
DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor with nanomolar-level inhibitory effects on mitochondrial complex I function in galactose-containing media, resulting in reduced ATP production, leading to impaired cellular energy metabolism and cancer cytotoxicity.
  • $293
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Fumarate hydratase-IN-1
T113371644060-37-6
Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor with antiproliferative activity and can be used to study cellular activity.
  • $30
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MFI8
T60503694488-83-0
MFI8 is a compound that regulates mitochondrial fission and can be used to study aging.
  • $75
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Ciprofloxacin
T164085721-33-1
Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). Ciprofloxacin is a highly active fluoroquinolone antibiotic.
  • $41
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BRD6897
T30583618395-82-7In house
BRD6897 is a mitochondrial content inducer that increases the cellular content of mitochondria and induces a significant increase in the electron density of existing mitochondria.
  • $392 TargetMol
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HQNO
T8433341-88-8
HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mitochondrial NDH-2 inhibitorin many species.
  • $50
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