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TargetMol | Tags Metabolism
ANGPTL
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ATP Citrate Lyase
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Acetyl-CoA Carboxylase
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Aconitase
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Acyltransferase
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Aminopeptidase
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Aminopeptidase

Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases).They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes.Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as Escherichia coli and mammals, particularly in catalytically important residues or in residues involved in metal ion binding.

Firibastat
T28482648927-86-0
Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].
  • $41
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Puromycin aminonucleoside
T1668458-60-6
Puromycin aminonucleoside (NSC 3056) is an aminonucleoside antibiotic and a purine analog of puromycin. It can reversibly inhibit dipeptidyl peptidase and cytosolic alanine aminopeptidase, increase podocyte permeability by regulating ZO-1 in an oxidative stress-dependent manner, induce apoptosis, and promote the secretion of migrasomes. It is commonly used to induce nephrotic syndrome models in research.
  • $39
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Bestatin hydrochloride
T352965391-42-6
Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
  • $47
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TargetMol | Citations Cited
Bestatin
T125758970-76-6
Bestatin (Ubenimex) competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage, and bone marrow stem cell as well as stimulates the release of interleukin-1 and -2, thus further enhances its antitumor activity.
  • $30
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LYS006
T96901799681-85-8
LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor, which can be used for neutrophil-driven inflammatory diseases such as ulcerative colitis.
  • $68
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Acebilustat
T3715943764-99-6
Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
  • $32
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Betulinic acid
T2830472-15-1
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.
  • $33
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α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
T60040128253-12-3In house
α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aided methodology.
  • $70
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Tosedostat
T6301238750-77-1
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Intracellularly converted into the poorly membrane-permeable active metabolite (CHR-79888), it inhibits puromycin-sensitive aminopeptidase (PuSA) and leukotriene A4 (LTA4) hydrolase. This inhibition in tumor cells may lead to amino acid deprivation, suppressed protein synthesis, increased proapoptotic protein Noxa levels, and ultimately, cell death.
  • $50
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N-Acetyl-β-Asp-Glu
T25964910-46-7
N-Acetyl-β-Asp-Glu is a peptide neurotransmitter, the third most common neurotransmitter in the mammalian nervous system. NAAG consists of N-acetylaspartate (NAA) and glutamate coupled via a peptide bond.
  • $29
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Batatasin IV
TN244460347-67-3
Batatasin IV is identified from Dioscorea opposita which is a a type of homologous medicinal plant and is commonly used as food in daily life.
  • $130
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DG051
TQ0047929915-58-2
DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor with an IC50 of 47 nM.
  • $31
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Aminopeptidase-IN-1
T61278374102-08-6
Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.
  • $39
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Bufexamac
T08672438-72-4
Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
  • $29
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SC-57461A
T21696423169-68-0
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
  • $35
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Acetyltrialanine
T2016319245-85-3
Acetyltrialanine is a dipeptide compound that binds at two sites on the Tb+3-pancreatic elastase complex and can be used as a nitrogen source.
  • $30
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ARM1
T2185968729-05-5
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
  • $30
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Methyl arachidate
T79581120-28-1
Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acid
  • $29
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L(+)-Leucinol
T56527533-40-6
L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.
  • $30
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SC-22716
T28698262451-89-8
SC-22716 is an orally active leukotriene A4 (LTA4) hydrolase inhibitor.SC-22716 has potential anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis.
  • $176
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Adamantanine
T2001342381-05-5
Adamantanine (NSC-145160) is an amino acid transport inhibitor.
  • $50
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ecMetAP-IN-1
T600217471-12-7
ecMetAP-IN-1 can be used as a QSAR model to study methionine aminopeptidase inhibitor as an anticancer agent using multiple linear regression.
  • $30
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HFI-142
T15479332164-34-8
HFI-142 is a small-molecule inhibitor that binds specifically to the active site of aminopeptidase N and suppresses its enzymatic activity. HFI-142 has been demonstrated to inhibit leukotriene A4 biosynthesis in red blood cells, an effect that may offer therapeutic potential for the research in cancer by modulating inflammatory and metabolic pathways implicated in tumor growth and progression. HFI-142 was also shown to inhibit the activity of additional aminopeptidases, including aminopeptidase N, as well as other enzymes associated with protein metabolism.
  • $59
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Ebelactone A
T3835276808-16-7
Ebelactone A, a mycolic acid β-lactone from Streptomyces sp., is a potent esterase inhibitor thatis capable of inhibiting esterase, lipase, and N-formylmethionine aminopeptidase activity, commonly used as a low-toxicity antibiotic.
  • $223
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