PF-4693627

Name: PF-4693627
Brand: TargetMol
SKU: T16504
Rating: 4.5 (1 reviews)

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Catalog No. T16504Cas No. 1312815-93-2

PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).

PF-4693627

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Catalog No. T16504Cas No. 1312815-93-2

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$133	35 days	35 days
1 mg	$246	35 days	35 days
5 mg	$1,150	35 days	35 days
10 mg	$2,160	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
Targets&IC50	mPGES-1:3 nM
In vitro	PF-4693627 displays high activity in lipopolysaccharide (LPS) stimulated human whole blood (HWB) cell assay (IC50=109 nM). PF-4693627 also inhibits mPGES-1 (IC50s: 180 and 6 nM in HWB-1483 and human fetal fibroblast, respectively).
In vivo	PF-4693627 (1.0 mg/kg; i.v.) displays good bioavailability (59%) and modest half-life (t1/2=3.7 h) in Sprague-Dawley rats. PF-4693627 (10 mg/kg; orally) suppresses 63% of PGE2 production relative to vehicle control in the Guinea pig carrageenan stimulated air pouch model[1].

Chemical Properties

Molecular Weight	502.43
Formula	C₂₆H₂₉Cl₂N₃O₃
Cas No.	1312815-93-2
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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