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Lexatumumab (GHS-ETR 2) is a human excitatory monoclonal antibody targeting TRAIL receptor 2 that has anticancer activity and induces apoptosis in malignant mesothelioma. Lexatumumab can be used to study malignant pleural mesothelioma (MPM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 247.00 | |
5 mg | In stock | $ 647.00 | |
10 mg | In stock | $ 987.00 |
Description | Lexatumumab (GHS-ETR 2) is a human excitatory monoclonal antibody targeting TRAIL receptor 2 that has anticancer activity and induces apoptosis in malignant mesothelioma. Lexatumumab can be used to study malignant pleural mesothelioma (MPM). |
In vitro |
Combining lexatumumab with cisplatin can synergistically inhibit cell growth and enhance apoptosis and death[1]. In different melanoma cell lines, lexatumumab (0-10 μg/ml, 72 h) induced varying degrees of cell death[2]. |
In vivo | Lexatumumab ( 10mg / kg, intravenous injection, twice a week ) combined with Dacarbazine can increase the anti-tumor effect in mice [ 2 ]. |
Synonyms | ETR2-ST01, DR5 mAB, HGS-ETR 2 |
Molecular Weight | 143.6 (kDa) |
CAS No. | 845816-02-6 |
store at low temperature
store at -80°C
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Lexatumumab 845816-02-6 Apoptosis ETR2-ST01 DR5 mAB HGS-ETR 2 inhibitor inhibit