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Synonyms: Myostatin, Mstn, GDF-8, GDF8


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $182 | 7-10 days | 7-10 days | |
| 10 µg | $286 | 7-10 days | 7-10 days | |
| 20 µg | $448 | 7-10 days | 7-10 days | |
| 50 µg | $829 | 7-10 days | 7-10 days | |
| 100 µg | $1,320 | 7-10 days | 7-10 days | |
| 200 µg | $2,090 | 7-10 days | 7-10 days | |
| 500 µg | $3,920 | 7-10 days | 7-10 days |
| Bioactivity | Immobilized Human/Cynomolgus Activin RIIB, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human/Cynomolgus/Mouse/Rat GDF-8, Avi Tag with the EC50 of 2.5 ng/ml determined by ELISA (QC Test). |
| Description | GDF-8 Protein, Human/Cynomolgus/Mouse/Rat, Recombinant (Avi), Biotinylated is expressed in HEK293 Cells. The accession number is O14793(Human)/Q95J86(Cynomolgus)/O08689(Mouse)/O35312(Rat). |
| Species | Human/Cynomolgus/Mouse/Rat |
| Expression System | HEK293 Cells |
| Tag | C-Avi |
| Accession Number | O14793(Human)/Q95J86(Cynomolgus)/O08689(Mouse)/O35312(Rat) |
| Construction | Asp267-Ser375 (Human/Cynomolgus)/Asp268-Ser376 (Mouse/Rat) |
| Protein Purity | > 95% as determined by Bis-Tris PAGE |
| Endotoxin | < 1 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in 4 mM HCL. Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in 4 mM HCL. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | Myostatin, Mstn, GDF-8, GDF8 |
| Research Background | Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain. GDF8, like numerous TGF-β family members, is a disulfidelinked dimer that is synthesized as a precursor protein which requires cleavage by a furin-like protease to yield an N-terminal prodomain and a C-terminal mature, signaling domain. |
| Molecular Weight | 14.21 kDa (Predicted); 15-18 kDa (Reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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