Shopping Cart

Remove All
Your shopping cart is currently empty

Subasumstat

Name: Subasumstat
Brand: TargetMol
SKU: T8428
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8428Cas No. 1858276-04-6

Alias TAK-981

Subasumstat (TAK-981), a selective inhibitor of the SUMOylation enzymatic cascade, has potential immune-activating and antineoplastic activities.

Subasumstat

🥰Excellent

Purity: 98.22%

Catalog No. T8428Alias TAK-981Cas No. 1858276-04-6

Subasumstat (TAK-981), a selective inhibitor of the SUMOylation enzymatic cascade, has potential immune-activating and antineoplastic activities.

Pack Size	Price	Availability
1 mg	$76	In Stock
2 mg	$108	In Stock
5 mg	$163	In Stock
10 mg	$255	In Stock
25 mg	$478	In Stock
50 mg	$689	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.22%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Subasumstat (TAK-981), a selective inhibitor of the SUMOylation enzymatic cascade, has potential immune-activating and antineoplastic activities.
In vitro	TAK-981 is able to increase the production of type 1 IFN, thereby increasing type 1 IFN-mediated signaling, TAK-981 activating innate effector cells and enhancing the antitumor innate immune responses[1].
In vivo	TAK-981(A single sub-cutaneous injection) in naive Balb/c mice at the brachial lymph nodes induces activation of DCs[2].
Synonyms	TAK-981

Chemical Properties

Molecular Weight	578.1
Formula	C₂₅H₂₈ClN₅O₅S₂
Cas No.	1858276-04-6
Smiles	Cc1sc(cc1[C@@H]1NCCc2ccc(Cl)cc12)C(=O)c1cncnc1N[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)C1
Relative Density.	1.474 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (69.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7298 mL	8.6490 mL	17.2980 mL	86.4902 mL
5 mM	0.3460 mL	1.7298 mL	3.4596 mL	17.2980 mL
10 mM	0.1730 mL	0.8649 mL	1.7298 mL	8.6490 mL
20 mM	0.0865 mL	0.4325 mL	0.8649 mL	4.3245 mL
50 mM	0.0346 mL	0.1730 mL	0.3460 mL	1.7298 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc