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XST-14

Name: XST-14
Brand: TargetMol
SKU: T60604
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60604Cas No. 2607143-50-8

XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells.

XST-14

🥰Excellent

Purity: 99.84%

Catalog No. T60604Cas No. 2607143-50-8

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$119	In Stock
10 mg	$182	In Stock
25 mg	$328	In Stock
50 mg	$496	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.84%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells.
Targets&IC50	ULK1:26.6 nM
In vitro	Treatment of HepG2 cells with XST-14 (5 μM) alone or in combination with sorafenib (5 μM) for 24 hours showed a synergistic effect, indicating that XST-14 in combination with sorafenib can inhibit HCC in vitro[1].
In vivo	BALB/c mice were treated with XST-14 (30 mg/kg, IP, every other day), sorafenib (30 mg/kg, P.O), or a combination of sorafenib (30 mg/kg, P.O) and XST-14 (30 mg/kg, IP) for 2 weeks. The results indicate that XST-14 exhibits favorable drug metabolism and pharmacokinetic (DMPK) properties, with no significant toxicity observed on liver/kidney function or body weight.

Chemical Properties

Molecular Weight	291.34
Formula	C₁₆H₂₁NO₄
Cas No.	2607143-50-8
Smiles	COC(=O)c1cc2c(OC(C)C)cc(OC(C)C)cc2[nH]1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (274.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4324 mL	17.1621 mL	34.3242 mL	171.6208 mL
5 mM	0.6865 mL	3.4324 mL	6.8648 mL	34.3242 mL
10 mM	0.3432 mL	1.7162 mL	3.4324 mL	17.1621 mL
20 mM	0.1716 mL	0.8581 mL	1.7162 mL	8.5810 mL
50 mM	0.0686 mL	0.3432 mL	0.6865 mL	3.4324 mL
100 mM	0.0343 mL	0.1716 mL	0.3432 mL	1.7162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc