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BTZO-1
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Catalog No. T7845Cas No. 99420-15-2
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
BTZO-1
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Purity: 99.46%
Catalog No. T7845Cas No. 99420-15-2
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $48 | In Stock | In Stock | |
| 10 mg | $82 | In Stock | In Stock | |
| 25 mg | $165 | In Stock | In Stock | |
| 50 mg | $247 | In Stock | In Stock | |
| 100 mg | $368 | In Stock | In Stock | |
| 200 mg | $523 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.46%
Appearance:Solid
Color:White
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Product Introduction
BTZO-1 AI Summary
BTZO-1 exhibits a range of bioactivities and interactions across different assays. It demonstrates varied effects on cell viability, indicating both growth inhibition (Growth Rate = 0.0) and promotion (Growth Rate = 1.0) in cell lines such as HEK293T, U2OS, and human fibroblasts. This implies that the compound's influence on cell growth is context-dependent. In thermal shift assays targeting specific protein domains, the compound causes diverse changes in melting temperatures (Delta TM), suggesting complex protein interactions. Additionally, in phenotypic cellular assays, it shows an IC50 value of 16.0 nM for apoptosis inhibition in MEC1.5 cells. Biochemically, BTZO-1 binds selectively to human MIF-His with a Kd value of 68.6 nM, as measured by [83H]-BTZO-1 binding. Furthermore, it exhibits selectivity in various bioactivity assays, showing 36.0% of control in CDK8, 47.0% of control in EIF2AK4, and a Ki value of 934.0 nM in GABRA1 assays. These diverse bioactivities underscore the compound's complex interaction profile and potential for multi-target effects..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity. |
| Targets&IC50 | MIF:68.6 nM (Kd) |
| Molecular Weight | 240.28 |
| Formula | C13H8N2OS |
| Cas No. | 99420-15-2 |
| Smiles | O=c1nc(sc2ccccc12)-c1ccccn1 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8.33 mg/mL (34.67 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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