Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
Description | IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53. |
In vitro | IRES-C11 (50 nM) significantly inhibits both cyclin D1 and c-MYC IRES activity. IRES-C11 treatment induces a significant shift in both cyclin D1 and c-MYC mRNA to monosomal/nonribosomal fractions, whereas actin mRNA distribution is unaffected. IRES-C11 inhibits both cyclin D1 and c-MYC IRES-mediated mRNA translation, leading to reductions in protein levels. Mechanistic studies with IRES-C11 reveal the binding of the inhibitors within the UP1 fragment of heterogeneous nuclear ribonucleoprotein A1.[1] |
Synonyms | IRES-C11 |
Molecular Weight | 316.14 |
Formula | C13H11Cl2NO4 |
CAS No. | 342416-30-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (711.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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IRES-C11 342416-30-2 Cell Cycle/Checkpoint c-Myc IRES-C-11 IRESC11 IRES C11 inhibitor inhibit