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4'-bromo-Resveratrol

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Catalog No. T21679Cas No. 1224713-90-9

4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)

4'-bromo-Resveratrol

4'-bromo-Resveratrol

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Purity: 99.00%
Catalog No. T21679Cas No. 1224713-90-9
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$41In StockIn Stock
10 mg$65In StockIn Stock
25 mg$137In StockIn Stock
50 mg$223In StockIn Stock
100 mg$358In StockIn Stock
1 mL x 10 mM (in DMSO)$45In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.00%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
In vitro
4'-BR treatment of melanoma cells resulted in (a) decrease in proliferation and clonogenic survival;?(b) induction of apoptosis accompanied by a decrease in procaspase-3, procaspase-8, and increase in the cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP);?(c) marked downregulation of proliferating cell nuclear antigen (PCNA);?and (d) inhibition of melanoma cell migration.?Further, 4'-BR caused a G0/G1 phase arrest of melanoma cells that was accompanied by an increase in WAF-1/P21 and decrease in Cyclin D1/Cyclin-dependent kinase 6 protein levels.?4'-BR causes a decrease in lactate production, glucose uptake, and NAD+ /NADH ratio.?These responses were accompanied by downregulation in lactate dehydrogenase A and glucose transporter 1 in melanoma cells.[1]
Chemical Properties
Molecular Weight291.14
FormulaC14H11BrO2
Cas No.1224713-90-9
SmilesOc1cc(O)cc(\C=C\c2ccc(Br)cc2)c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (103.04 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4348 mL17.1739 mL34.3477 mL171.7387 mL
5 mM0.6870 mL3.4348 mL6.8695 mL34.3477 mL
10 mM0.3435 mL1.7174 mL3.4348 mL17.1739 mL
20 mM0.1717 mL0.8587 mL1.7174 mL8.5869 mL
50 mM0.0687 mL0.3435 mL0.6870 mL3.4348 mL
100 mM0.0343 mL0.1717 mL0.3435 mL1.7174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Sirtuin-3Sirtuin-1SirtuinSIRT3SIRT1mitochondrial metabolic reprogrammingmelanoma cell growthInhibitorinhibitcell cycleApoptosisantiproliferative4'-bromo-Resveratrol4'bromoResveratrol4′‐BR4' bromo Resveratrol
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