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PROTAC SGK3 degrader-1

Name: PROTAC SGK3 degrader-1
Brand: TargetMol
SKU: T13847
Rating: 4.5 (1 reviews)

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Catalog No. T13847Cas No. 2381320-35-8

Alias SGK3-PROTAC1

PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]

PROTAC SGK3 degrader-1

😃Good

Catalog No. T13847Alias SGK3-PROTAC1Cas No. 2381320-35-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$479	Inquiry	Inquiry
5 mg	$977	Inquiry	Inquiry
25 mg	$2,280	Inquiry	Inquiry
50 mg	$2,970	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$39	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]
In vitro	SGK3-PROTAC1 (0.3 μM) induces endogenous SGK3 degradation by 50% within 2 hours, with maximal degradation of 80% observed within 8 hours, accompanied by loss of phosphorylation of SGK3 substrate NDRG1[1].
Synonyms	SGK3-PROTAC1

Chemical Properties

Molecular Weight	1157.38
Formula	C₅₇H₇₃FN₁₀O₁₁S₂
Cas No.	2381320-35-8
Smiles	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCCCCCN2CCO[C@@H](COc3nc(nc4[nH]ncc34)-c3ccc(NS(=O)(=O)c4cc(C)ccc4F)cc3)C2)C(C)(C)C)cc1
Relative Density.	1.309 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (69.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8640 mL	4.3201 mL	8.6402 mL	43.2010 mL
5 mM	0.1728 mL	0.8640 mL	1.7280 mL	8.6402 mL
10 mM	0.0864 mL	0.4320 mL	0.8640 mL	4.3201 mL
20 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1601 mL
50 mM	0.0173 mL	0.0864 mL	0.1728 mL	0.8640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc