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PROTAC SGK3 degrader-1

Name: PROTAC SGK3 degrader-1
Brand: TargetMol
SKU: T13847
Rating: 4.5 (1 reviews)

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Catalog No. T13847Cas No. 2381320-35-8

Alias SGK3-PROTAC1

PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]

PROTAC SGK3 degrader-1

😃Good

Catalog No. T13847Alias SGK3-PROTAC1Cas No. 2381320-35-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$479	Inquiry	Inquiry
5 mg	$977	Inquiry	Inquiry
25 mg	$2,280	Inquiry	Inquiry
50 mg	$2,970	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$39	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]
In vitro	SGK3-PROTAC1 (0.3 μM) induces endogenous SGK3 degradation by 50% within 2 hours, with maximal degradation of 80% observed within 8 hours, accompanied by loss of phosphorylation of SGK3 substrate NDRG1[1].
Synonyms	SGK3-PROTAC1

Chemical Properties

Molecular Weight	1157.38
Formula	C₅₇H₇₃FN₁₀O₁₁S₂
Cas No.	2381320-35-8
Relative Density.	1.309 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (69.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.85 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8640 mL	4.3201 mL	8.6402 mL	43.2010 mL
5 mM	0.1728 mL	0.8640 mL	1.7280 mL	8.6402 mL
10 mM	0.0864 mL	0.4320 mL	0.8640 mL	4.3201 mL
20 mM	0.0432 mL	0.2160 mL	0.4320 mL	2.1601 mL
50 mM	0.0173 mL	0.0864 mL	0.1728 mL	0.8640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc