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Bisindolylmaleimide VIII

🥰Excellent
TargetMol
Catalog No. T71125Cas No. 125313-65-7
Alias RO 318161, Ro 31-7549, Bis VIII

Bisindolylmaleimide VIII (Ro-31-7549) is a selective and potent protein kinase C (PKC) inhibitor with good inhibition of PKC-α, PKC-β I, PKC-β II, PKC-γ, and PKC-ε.Bisindolylmaleimide VIII Bisindolylmaleimide VIII inhibits T cell-mediated autoimmune diseases and enhances Fas-mediated apoptosis through a protein kinase C-independent mechanism.

Bisindolylmaleimide VIII
Other Forms of Bisindolylmaleimide VIII:
Bisindolylmaleimide VIII acetateT10549138516-31-1
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Bisindolylmaleimide VIII

🥰Excellent
TargetMol
Purity: 98.01%
Catalog No. T71125Alias RO 318161, Ro 31-7549, Bis VIIICas No. 125313-65-7
Bisindolylmaleimide VIII (Ro-31-7549) is a selective and potent protein kinase C (PKC) inhibitor with good inhibition of PKC-α, PKC-β I, PKC-β II, PKC-γ, and PKC-ε.Bisindolylmaleimide VIII Bisindolylmaleimide VIII inhibits T cell-mediated autoimmune diseases and enhances Fas-mediated apoptosis through a protein kinase C-independent mechanism.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$293In StockIn Stock
5 mg$722In StockIn Stock
10 mg$987In StockIn Stock
25 mg$1,520In StockIn Stock
50 mg$1,980In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.01%
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Product Introduction

Bioactivity
Description
Bisindolylmaleimide VIII (Ro-31-7549) is a selective and potent protein kinase C (PKC) inhibitor with good inhibition of PKC-α, PKC-β I, PKC-β II, PKC-γ, and PKC-ε.Bisindolylmaleimide VIII Bisindolylmaleimide VIII inhibits T cell-mediated autoimmune diseases and enhances Fas-mediated apoptosis through a protein kinase C-independent mechanism.
Targets&IC50
PKCγ:213 nM, PKCε:175 nM, PKCβI:195 nM, PKCα:53 nM, PKC (rat brain):158 nM, PKCβII:163 nM
In vitro
Ro-31-7549 (5 μM; 8, 12h; 1321N1 cells) significantly increases TRA-8-induced cell death in a time- and dose-dependent manner.[2]
After combined treatment with Ro-31-7549 (5 μM; 6h; 1321N1 cells) and TRA-8, procaspase-8 was significantly reduced at 4 h and completely disappeared at 6h.[2]
In vivo
Ro-31-7549 (100 μg; i.p.; every other day for three doses; 6-8-week-old female NOD/SCID mice) combined with toTRA-8, resulted in nearly complete tumor regression. Bisindolylmaleimide VIII alone did not result in significant tumor regression.[2]
SynonymsRO 318161, Ro 31-7549, Bis VIII
Chemical Properties
Molecular Weight398.46
FormulaC24H22N4O2
Cas No.125313-65-7
SmilesO=C1NC(=O)C(C2=CN(C=3C=CC=CC23)CCCN)=C1C4=CN(C=5C=CC=CC45)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

VortexUNII-FC61260G4QRo-31-7549 MonohydrateRo-31-7549PKCApoptosis
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