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BD1063 dhydrochloride

Name: BD1063 dhydrochloride
Brand: TargetMol
SKU: T7488
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7488Cas No. 206996-13-6

Alias BD1063 2HCL

BD1063 dihydrochloride is a potent and selective sigma 1 (σ1) receptor antagonist (Ki = 9 nM).

BD1063 dhydrochloride

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Purity: 99.52%

Catalog No. T7488Alias BD1063 2HCLCas No. 206996-13-6

BD1063 dihydrochloride is a potent and selective sigma 1 (σ1) receptor antagonist (Ki = 9 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$41	In Stock	In Stock
5 mg	$66	In Stock	In Stock
10 mg	$92	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$357	In Stock	In Stock
100 mg	$525	In Stock	In Stock
200 mg	$739	In Stock	In Stock
500 mg	$1,130	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	BD1063 dihydrochloride is a potent and selective sigma 1 (σ1) receptor antagonist (Ki = 9 nM).
In vivo	BD 1063 dose-dependently reduced ethanol self-administration in sP rats (3.3–11 mg/kg) and withdrawn, dependent Wistar rats (4–11 mg/kg) at doses that did not modify mean ethanol self-administration in non-dependent Wistar controls[1]
Animal Research	Rats (controls, N=11;?dependent, N=9) were pretreated with BD-1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights) using a within-subject Latin square design.?sP rats: Rats (N=9) were pretreated with BD-1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis) using a within-subject Latin square design[1].
Synonyms	BD1063 2HCL

Chemical Properties

Molecular Weight	346.12
Formula	C₁₃H₂₀Cl₄N₂
Cas No.	206996-13-6
Smiles	Cl.Cl.CN1CCN(CCc2ccc(Cl)c(Cl)c2)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (144.46 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.8892 mL	14.4459 mL	28.8917 mL	144.4586 mL
5 mM	0.5778 mL	2.8892 mL	5.7783 mL	28.8917 mL
10 mM	0.2889 mL	1.4446 mL	2.8892 mL	14.4459 mL
20 mM	0.1445 mL	0.7223 mL	1.4446 mL	7.2229 mL
50 mM	0.0578 mL	0.2889 mL	0.5778 mL	2.8892 mL
100 mM	0.0289 mL	0.1445 mL	0.2889 mL	1.4446 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc