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UK 356618

Name: UK 356618
Brand: TargetMol
SKU: T17201
Rating: 4.5 (1 reviews)

(Synonyms: UK-356618, UK356618) Copy Product Info

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Synonyms: UK-356618, UK356618

Catalog No. T17201 Copy Product Info

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UK 356618 is a potent and selective matrix metalloproteinase 3 (MMP-3) inhibitor with an IC50 of 5.9 nM. Its inhibitory activities against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 are all weaker than that against MMP-3.

Cas No. 230961-08-7

Pack Size	Price	USA Stock	Global Stock
5 mg	$971	35 days	35 days
10 mg	$1,400	35 days	35 days
25 mg	$2,260	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	UK 356618 is a potent and selective matrix metalloproteinase 3 (MMP-3) inhibitor with an IC50 of 5.9 nM. Its inhibitory activities against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 are all weaker than that against MMP-3.
Targets & IC50	MMP2:1.79 μM, MMP14:1.9 μM, MMP13:73 nM, MMP1:51 μM, MMP9:0.84 μM, MMP3:5.9 nM
In vitro	Methods: In vitro cell experiments and molecular interaction studies were performed to explore the effects of substituent size on MMP‑3 inhibitory activity and MMP‑2 selectivity, as well as the pharmacological characteristics of UK 356618 against MMPs and its effect on TNF‑α‑induced lung cancer cell migration. Results: : 1.The inhibitory activity against MMP‑3 and the selectivity for matrix metalloproteinase 2 (MMP‑2) were highly sensitive to substituent size, among which methyl substitution showed the optimal effect (corresponding compound UK 356618). Compared with other matrix metalloproteinases (MMPs), UK 356618 exhibited a broader spectrum of action [1]. 2.MMP‑13 is closely associated with tumor metastasis‑related interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α). MMP‑13 knockout abolished the promotive effect of TNF‑α on lung cancer cell migration, and treatment with UK 356618 also effectively blocked the migration of NCI‑H446 lung cancer cells induced by TNF‑α [2].
In vivo	Methods: Male Wistar rats were intravenously administered UK 356618 at a dose of 15 mg/kg. Reperfusion was performed at 24 hours and 7 days after administration, and the effect on MMP3 activity in the rat brain was detected. Results: After intravenous injection of UK 356618 at 15 mg/kg followed by reperfusion at 24 hours and 7 days respectively, MMP3 activity in the brain of male Wistar rats was significantly reduced [3].
Synonyms	UK-356618, UK356618

Chemical Properties

Molecular Weight	557.72
Formula	C₃₄H₄₃N₃O₄
Cas No.	230961-08-7
Smiles	CC1=C(C=CC(CCC[C@@H](C(N[C@H](C(N[C@H](C)C2=CC=CC=C2)=O)[C@@](C)(C)C)=O)CC(NO)=O)=C1)C3=CC=CC=C3
Relative Density.	1.124 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (35.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7930 mL	8.9651 mL	17.9301 mL	89.6507 mL
5 mM	0.3586 mL	1.7930 mL	3.5860 mL	17.9301 mL
10 mM	0.1793 mL	0.8965 mL	1.7930 mL	8.9651 mL
20 mM	0.0897 mL	0.4483 mL	0.8965 mL	4.4825 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.