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UK-101
🥰Excellent
Catalog No. T13247Cas No. 1000313-40-5
Alias UK101, UK 101
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.
UK-101
🥰Excellent
Purity: 99.25%
Catalog No. T13247Alias UK101, UK 101Cas No. 1000313-40-5
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $239 | In Stock | |
| 5 mg | $446 | In Stock | |
| 10 mg | $718 | In Stock | |
| 25 mg | $1,450 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.25%
ee:98.78%
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Product Introduction
Bioactivity
Chemical Properties
| Description | UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases. |
| Targets&IC50 | LMP2:104 nM, Immunoproteasome β1c:15 μM, Immunoproteasome β5:1 μM |
| In vitro | In the G1 phase of the cell cycle, UK-101 (2-8 μM; 24 hours) induces cell cycle arrest and increases the number of the PC-3 cell arrest.UK-101 (1-8 μM; 24 hours) induces cell accumulation in the G1 phase of the cell cycle, it increases p27 accumulation and significantly increases PARP cleavage as a dose-dependent manner.[1] |
| In vivo | Tumor volume as a dose-dependent manner decreased by UK-101 (1-3 mg/kg; twice a week; 3 weeks)intraperitoneal injection, it significantly decreases tumor volume at a dose of 3 mg/kg. Additionally, UK-101-treated mice are suffering less systemic toxicity and the weights of mice treated with UK-101 remain steady over the 3-week treatment period.[1] |
| Synonyms | UK101, UK 101 |
| Molecular Weight | 484.74 |
| Formula | C25H48N2O5Si |
| Cas No. | 1000313-40-5 |
| Smiles | C([C@@H](NC([C@@H](NC(CCCCCC)=O)C)=O)CC(C)C)(=O)[C@@]1(CO[Si](C(C)(C)C)(C)C)CO1 |
| Relative Density. | 1.009 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 237.5 mg/mL (489.95 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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