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UK-101

Name: UK-101
Brand: TargetMol
SKU: T13247
Price: 239 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: UK101, UK 101) Copy Product Info

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Synonyms: UK101, UK 101

Catalog No. T13247 Copy Product Info

Purity: 99.08%

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UK-101 is a small molecule inhibitor and a selective inhibitor of the immunoproteasome β1i (LMP2) subunit (IC50=104 nM), with 144-fold and 10-fold selectivity over the β1c and β5 subunits, respectively. This compound can induce apoptosis, possesses antitumor activity, and can be used for prostate cancer-related research.

Cas No. 1000313-40-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$239	In Stock	In Stock
5 mg	$446	In Stock	In Stock
10 mg	$718	In Stock	In Stock
25 mg	$1,450	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.08%

ee:99.42%

Color:White

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	UK-101 is a small molecule inhibitor and a selective inhibitor of the immunoproteasome β1i (LMP2) subunit (IC50=104 nM), with 144-fold and 10-fold selectivity over the β1c and β5 subunits, respectively. This compound can induce apoptosis, possesses antitumor activity, and can be used for prostate cancer-related research.
Targets & IC50	Immunoproteasome β1c:15 μM, LMP2:104 nM, Immunoproteasome β5:1 μM
In vitro	Methods: PC-3 cells were treated with various concentrations of UK-101 (1-8 μM) for 24 hours, and cell cycle distribution, p27 protein accumulation, and PARP cleavage were detected. Results: UK-101 induced cell cycle arrest at the G1 phase, increased the number of cells in the G1 phase, enhanced p27 protein accumulation, and significantly increased PARP cleavage in a dose-dependent manner.[1]
In vivo	Methods: To detect the in vivo antitumor activity and toxicity of UK-101, tumor-bearing mice were intraperitoneally injected with UK-101 (1-3 mg/kg, twice weekly for 3 weeks), tumor volume changes were measured, and mouse body weight was monitored. Results: UK-101 treatment reduced tumor volume in a dose-dependent manner, with significant tumor volume reduction at the 3 mg/kg dose; meanwhile, mouse body weight remained stable during the treatment period, indicating low systemic toxicity.[1]
Synonyms	UK101, UK 101

Chemical Properties

Molecular Weight	484.74
Formula	C₂₅H₄₈N₂O₅Si
Cas No.	1000313-40-5
Smiles	C([C@@H](NC([C@@H](NC(CCCCCC)=O)C)=O)CC(C)C)(=O)[C@@]1(CO[Si](C(C)(C)C)(C)C)CO1
Relative Density.	1.009 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 237.5 mg/mL (489.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0630 mL	10.3148 mL	20.6296 mL	103.1481 mL
5 mM	0.4126 mL	2.0630 mL	4.1259 mL	20.6296 mL
10 mM	0.2063 mL	1.0315 mL	2.0630 mL	10.3148 mL
20 mM	0.1031 mL	0.5157 mL	1.0315 mL	5.1574 mL
50 mM	0.0413 mL	0.2063 mL	0.4126 mL	2.0630 mL
100 mM	0.0206 mL	0.1031 mL	0.2063 mL	1.0315 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.