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1-(1-Naphthyl) piperazine hydrochloride
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Catalog No. T21569Cas No. 104113-71-5
Alias 1-naphthalen-1-ylpiperazine hydrochloride, 1-(Naphthalen-1-yl)piperazine hydrochloride
1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors.
1-(1-Naphthyl) piperazine hydrochloride
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Purity: 98.27%
Catalog No. T21569Alias 1-naphthalen-1-ylpiperazine hydrochloride, 1-(Naphthalen-1-yl)piperazine hydrochlorideCas No. 104113-71-5
1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $31 | In Stock | In Stock | |
| 25 mg | $54 | In Stock | In Stock | |
| 50 mg | $81 | In Stock | In Stock | |
| 100 mg | $120 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.27%
Appearance:Solid
Color:Yellow
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Product Introduction
1-(1-Naphthyl) piperazine hydrochloride AI Summary
1-(1-Naphthyl) piperazine hydrochloride exhibits a diverse range of bioactivities. It shows antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 7943.28 nM to 15848.93 nM after 72 hours. It also inhibits the proliferation of Plasmodium falciparum lines Dd2, 3D7, W2, 7G8, and D10, with potencies ranging from 7943.3 nM to 17782.8 nM. Additionally, 1-(1-Naphthyl) piperazine hydrochloride acts as a modulator of Lamin A splicing (5.6 nM), inhibitor of Jumonji Domain Containing 2E (25118.9 nM), and inducer of genomic imprint erasure (12589.3 nM). It also inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) (35481.3 nM), Human Peripheral Myelin Protein 22 (PMP22) expression/activity (42561.5 nM), Influenza NS1 protein function (35481.3 nM), HPGD activity (28183.8 nM to 3768.6 nM), MPP8 chromodomain interactions (79432.8 nM), Histone Lysine Methyltransferase G9a (10000.0 nM), HP1-beta chromodomain interactions (100000.0 nM), and Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) with potencies of 28183.8 nM and 3768.6 nM. Moreover, 1-(1-Naphthyl) piperazine hydrochloride inhibits Polymerase Iota (25118.9 nM), the Human hERG channel (35481.3 nM), Marburg Virus binding/entry (11220.2 nM to 29081.0 nM), mitochondrial permeability transition pore (IC50 of 80000.0 nM), and Hepatitis C Virus (HCV) (10000.0 nM). In addition, it induces DNA re-replication in MCF 10a normal breast cells (231.1 nM) and SW480 colon adenocarcinoma cells (5.8 nM). It also functions as an inhibitor of GLP-1 receptor inverse agonists (7079.5 nM) and human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells, both with and without CPT, displaying potencies of 9200.0 nM and 29092.9 nM, respectively..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors. |
| Synonyms | 1-naphthalen-1-ylpiperazine hydrochloride, 1-(Naphthalen-1-yl)piperazine hydrochloride |
| Molecular Weight | 248.75 |
| Formula | C14H17ClN2 |
| Cas No. | 104113-71-5 |
| Smiles | Cl.C1CN(CCN1)C1=CC=CC2=CC=CC=C12 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (120.6 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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