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Anti-DGCR8 Antibody (2I601)
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Catalog No. TMAH-00343
Alias pasha, Microprocessor complex subunit DGCR8, Gy1, DiGeorge syndrome critical region gene 8, DiGeorge syndrome critical region 8, DGCRK 6, DGCR8 microprocessor complex subunit, DGCR 8, D16Wis2, D16H22S788E, C22orf12
Anti-DGCR8 Antibody (2I601) is an antibody targeting DGCR8. Anti-DGCR8 Antibody (2I601) can be used in ELISA, WB.
Anti-DGCR8 Antibody (2I601)
Anti-DGCR8 Antibody (2I601)
😃Good
Catalog No. TMAH-00343Alias pasha, Microprocessor complex subunit DGCR8, Gy1, DiGeorge syndrome critical region gene 8, DiGeorge syndrome critical region 8, DGCRK 6, DGCR8 microprocessor complex subunit, DGCR 8, D16Wis2, D16H22S788E, C22orf12
Anti-DGCR8 Antibody (2I601) is an antibody targeting DGCR8. Anti-DGCR8 Antibody (2I601) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB Reactivity: Human |
| Alias | pasha, Microprocessor complex subunit DGCR8, Gy1, DiGeorge syndrome critical region gene 8, DiGeorge syndrome critical region 8, DGCRK 6, DGCR8 microprocessor complex subunit, DGCR 8, D16Wis2, D16H22S788E, C22orf12 |
| Ig Type | Rabbit IgG |
| Clone | 2I601 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in: K562 whole cell lysate -All lanes: DGCR8 antibody at 2.65μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 87, 33, 83 KDa -Observed band size: 100 KDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. Nucleus, nucleolus. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994). |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing. Involved in the silencing of embryonic stem cell self-renewal. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human DGCR8 |
| Antigen Species | Human |
| Gene ID | 54487 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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