Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,140.00 | |
50 mg | 10-14 weeks | $ 2,785.00 | |
100 mg | 10-14 weeks | $ 3,520.00 |
Description | L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM. |
In vitro | L-I-OddU, at a concentration of 1 μM in H1 cells, impedes the replication of the Epstein-Barr virus (EBV) and reduces the linear form of EBV DNA [1]. When administered to H1 and L5 cells at doses ranging from 0.25 to 2 μM for 24 hours, L-I-OddU predominantly metabolizes into L-I-OddUMP and elevates the production of mono- and diphosphate metabolites in H1 cells in a dose-dependent fashion [1]. |
Molecular Weight | 340.07 |
Formula | C8H9IN2O5 |
CAS No. | 207920-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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L-I-OddU 207920-87-4 inhibitor inhibit