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N-Glycolylneuraminic acid

Name: N-Glycolylneuraminic acid
Brand: TargetMol
SKU: T19456
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19456Cas No. 1113-83-3

Alias NeuGc, GcNeu

N-Glycolylneuraminic acid (GcNeu) is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.

N-Glycolylneuraminic acid

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Purity: 99.94%

Catalog No. T19456Alias NeuGc, GcNeuCas No. 1113-83-3

N-Glycolylneuraminic acid (GcNeu) is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$77	In Stock
10 mg	$129	In Stock
25 mg	$245	In Stock
50 mg	$396	In Stock
100 mg	$579	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock

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Purity:99.94%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	N-Glycolylneuraminic acid (GcNeu) is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.
In vitro	Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells[1].
Synonyms	NeuGc, GcNeu

Chemical Properties

Molecular Weight	325.27
Formula	C₁₁H₁₉NO₁₀
Cas No.	1113-83-3
Smiles	OC[C@@H](O)[C@@H](O)[C@@H]1O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O
Relative Density.	1.670 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 76 mg/mL (233.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0744 mL	15.3718 mL	30.7437 mL	153.7184 mL
5 mM	0.6149 mL	3.0744 mL	6.1487 mL	30.7437 mL
10 mM	0.3074 mL	1.5372 mL	3.0744 mL	15.3718 mL
20 mM	0.1537 mL	0.7686 mL	1.5372 mL	7.6859 mL
50 mM	0.0615 mL	0.3074 mL	0.6149 mL	3.0744 mL
100 mM	0.0307 mL	0.1537 mL	0.3074 mL	1.5372 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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