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ADT-007

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Catalog No. T85316Cas No. 1945941-09-2
Alias ADT007, ADT 007

ADT-007 is an orally active and selective pan-RAS inhibitor with potent anticancer activity.ADT-007 blocks GTP activation of RAS and MAPK/AKT signaling by binding to anucleotide RAS.ADT-007 is used in the study of gastrointestinal cancers.

ADT-007

ADT-007

😃Good
Purity: 97.75%
Catalog No. T85316Alias ADT007, ADT 007Cas No. 1945941-09-2
ADT-007 is an orally active and selective pan-RAS inhibitor with potent anticancer activity.ADT-007 blocks GTP activation of RAS and MAPK/AKT signaling by binding to anucleotide RAS.ADT-007 is used in the study of gastrointestinal cancers.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$42In StockIn Stock
5 mg$93In StockIn Stock
10 mg$133In StockIn Stock
25 mg$223-In Stock
50 mg$392-In Stock
100 mg$668-In Stock
200 mg$1,090-In Stock
1 mL x 10 mM (in DMSO)$112In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.75%
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Product Introduction

Bioactivity
Description
ADT-007 is an orally active and selective pan-RAS inhibitor with potent anticancer activity.ADT-007 blocks GTP activation of RAS and MAPK/AKT signaling by binding to anucleotide RAS.ADT-007 is used in the study of gastrointestinal cancers.
In vivo
In 6-8-week-old BALB/C mice injected with colorectal cancer cells, ADT-007 (10 mg/kg; intra-tumoral injection; once a day; for 17-21 days) can strongly inhibit tumor growth[1].
SynonymsADT007, ADT 007
Chemical Properties
Molecular Weight449.47
FormulaC26H24FNO5
Cas No.1945941-09-2
SmilesC(=C/1\C=2C(C(CC(NCC3=CC=CO3)=O)=C1C)=CC(F)=CC2)\C4=CC(OC)=C(O)C(OC)=C4
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

RAS
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