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EBI-2511
🥰Excellent
Catalog No. T15194Cas No. 2098546-05-3
EBI-2511 is a highly potent, orally active inhibitor of EZH2, with an IC50 of 6 nM in Pfeffiera cell lines.
EBI-2511
🥰Excellent
Purity: 99.74%
Catalog No. T15194Cas No. 2098546-05-3
EBI-2511 is a highly potent, orally active inhibitor of EZH2, with an IC50 of 6 nM in Pfeffiera cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $123 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $372 | In Stock | |
| 50 mg | $579 | In Stock | |
| 100 mg | $823 | In Stock | |
| 200 mg | $1,090 | In Stock |
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Purity:99.74%
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Product Introduction
Bioactivity
Chemical Properties
| Description | EBI-2511 is a highly potent, orally active inhibitor of EZH2, with an IC50 of 6 nM in Pfeffiera cell lines. |
| Targets&IC50 | EZH2:6 nM (in cell) |
| In vitro | EBI-2511 obviously decreases cellular H3K27me3 levels in a dose-dependent manner (an approximate IC50: 8 nM) and it is 3-fold more potent than EPZ-6438. In addition to Pfeffier cell line, EBI-2511 was shown active against WSU-DLCL2 ( IC50: 55 nM) [1]. |
| In vivo | EBI-2511 demonstrates dose-dependent tumor growth inhibition, with tumor size reductions of 28% (10mg/kg), 83% (30mg/kg), and 97% (100mg/kg). No significant changes in body weights are observed across all treatment groups. At the same dosage, EBI-2511 shows superior anti-tumor efficacy compared to EPZ-6438 (P<0.01) [1]. |
| Molecular Weight | 576.77 |
| Formula | C34H48N4O4 |
| Cas No. | 2098546-05-3 |
| Smiles | CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC)C1CCN(CC1)C(C)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (8.67 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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