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DL-Syringaresinol
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Catalog No. TN1594Cas No. 1177-14-6
Alias (±)-Syringaresinol
DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin aging through autophagy, alleviate oxaliplatin-induced neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses. neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses.
DL-Syringaresinol
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Purity: 96.00%
Catalog No. TN1594Alias (±)-SyringaresinolCas No. 1177-14-6
DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin aging through autophagy, alleviate oxaliplatin-induced neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses. neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $196 | In Stock | In Stock | |
| 5 mg | $446 | In Stock | In Stock | |
| 10 mg | $645 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $493 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.00%
Appearance:Solid
Color:Yellow
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Product Introduction
DL-Syringaresinol AI Summary
DL-Syringaresinol demonstrates a diverse range of bioactivities and cytotoxic properties. It moderately stabilizes human topoisomerase I-DNA covalent complexes and induces DNA breakage, showing effects at 100 uM and 1 uM concentrations in the presence and absence of topoisomerase I, respectively. The compound is cytotoxic against various human cancer cell lines including PANC1, A549, MCF7, HT-29, and several others, with IC50 and ED50 values varying significantly across different cell lines, displaying notable activity particularly against human MCF7 cells (ED50 ~3.69 - 30.31 ug/mL). It also exhibits antiestrogenic activity by inhibiting cell proliferation in human MCF7 and T47D cells.
In addition to its antineoplastic properties, DL-Syringaresinol displays antitubercular activity against Mycobacterium tuberculosis strain 90-221387 with a MIC of 239290 nM. It possesses anti-inflammatory effects by inhibiting LPS-induced nitric oxide production in mouse RAW264.7 cells, with IC50 values ranging from 14800 nM to over 50000 nM. Furthermore, it shows antineuroinflammatory activity by inhibiting nitric oxide production in mouse N9 cells with an IC50 of 2680 nM.
The compound also has significant toxicity against brine shrimp larvae (LC50 ~0.65 - 13.6 ug/mL) and exhibits cytotoxic effects on mouse P388, B16-BL6, LLC, and various other cell lines. It activates PPARbeta in mouse C2C12 myotubes, indicating potential metabolic and mitochondrial biogenesis effects. The compound shows moderate inhibitory activity against Leishmania amazonensis arginase and weak or no inhibitory effect on mushroom tyrosinase. Additionally, it increases 2-NBDG uptake in mouse 3T3L1 cells and inhibits PTP1B with an IC50 of 15010 nM.
Despite its broad bioactivity profile, DL-Syringaresinol shows varying potency across different assays, cell lines, and conditions, necessitating further investigation to fully elucidate its therapeutic potential and safety profile..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin aging through autophagy, alleviate oxaliplatin-induced neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses. neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses. |
| Synonyms | (±)-Syringaresinol |
| Molecular Weight | 418.44 |
| Formula | C22H26O8 |
| Cas No. | 1177-14-6 |
| Smiles | O(C)C=1C=C([C@@H]2[C@@]3([C@@]([C@H](OC3)C4=CC(OC)=C(O)C(OC)=C4)(CO2)[H])[H])C=C(OC)C1O |
| Relative Density. | 1.282 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.19 mg/mL (10.01 mM), Sonication is recommended.  Methanol: 4.19 mg/mL (10.01 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/Methanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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