Shopping Cart

Your shopping cart is currently empty

BMS-986020

Name: BMS-986020
Brand: TargetMol
SKU: T4016
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T4016Cas No. 1257213-50-5

Alias BMS986020, AM152

BMS-986020 (AM152) is a selective LPA1 antagonist.

BMS-986020

Copy Product Info

🥰Excellent

Purity: 98.82%

Catalog No. T4016Alias BMS986020, AM152Cas No. 1257213-50-5

BMS-986020 (AM152) is a selective LPA1 antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	In Stock	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$556	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.82%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

BMS-986020 AI Summary

BMS-986020 exhibits a range of bioactivities, including: antagonist activity at the human LPA1 receptor with a Kb of 6.7 nM, low free fractions due to protein binding in human, rat, and mouse plasma, and inhibition of CYP enzymes such as CYP2B6, CYP2C9, and CYP2C8. Additionally, it inhibits transporters like BSEP, MDR3, MRP3, MRP4, OATP1B1, and OATP1B3, and induces CYP enzymes in human hepatocytes. It demonstrates anti-fibrotic activity in a rat model of bleomycin-induced lung fibrosis with 63.0% activity. The compound has a half-life in liver microsomes ranging from 1.267 to 1.517 hours, an aqueous solubility of 11.0 µg/mL at pH 7.4, and an AUC in Cynomolgus monkey plasma of 74000.0 ng.hr/mL. It also shows inhibition of hERG at 15 µM by 7.0% and has a lipophilicity with a log D of 3.6 at pH 6.5..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BMS-986020 (AM152) is a selective LPA1 antagonist.
Targets&IC50	MDR3:7.5 µM (IC50), MRP4:6.2 µM (IC50), BSEP:4.8 µM (IC50)
Synonyms	BMS986020, AM152

Chemical Properties

Molecular Weight	482.53
Formula	C₂₉H₂₆N₂O₅
Cas No.	1257213-50-5
Smiles	C[C@@H](OC(=O)Nc1c(C)noc1-c1ccc(cc1)-c1ccc(cc1)C1(CC1)C(O)=O)c1ccccc1
Relative Density.	1.309 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (103.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0724 mL	10.3621 mL	20.7241 mL	103.6205 mL
5 mM	0.4145 mL	2.0724 mL	4.1448 mL	20.7241 mL
10 mM	0.2072 mL	1.0362 mL	2.0724 mL	10.3621 mL
20 mM	0.1036 mL	0.5181 mL	1.0362 mL	5.1810 mL
50 mM	0.0414 mL	0.2072 mL	0.4145 mL	2.0724 mL
100 mM	0.0207 mL	0.1036 mL	0.2072 mL	1.0362 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc