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Solithromycin

Name: Solithromycin
Brand: TargetMol
SKU: T2331
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2331Cas No. 760981-83-7

Alias OP-1068, CEM-101

Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemophilus influenzae with IC50 values of 7.5 ng/mL, 40 ng/mL, and 125 ng/mL, respectively.Solithromycin inhibits protein biosynthesis by binding to the large 50S subunit of the ribosome.

Solithromycin

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Purity: 99.42%

Catalog No. T2331Alias OP-1068, CEM-101Cas No. 760981-83-7

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	In Stock	In Stock
5 mg	$51	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$178	In Stock	In Stock
50 mg	$293	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Solithromycin AI Summary

Solithromycin exhibits broad-spectrum antimicrobial activity, demonstrating efficacy against various bacterial strains, including Staphylococcus aureus (wild type and resistant strains), Escherichia coli, Acinetobacter baumannii, Enterococcus faecium, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Notably, it shows high potency with minimum inhibitory concentrations (MICs) ranging from 0.006 μg/mL to 9500 nM against different strains. The compound binds to the 70S ribosome of Escherichia coli with a dissociation constant (Kd) of 0.6 nM and inhibits ribosomal activity, reducing protein synthesis by 47%. It also binds to the Staphylococcus aureus 70S ribosome with a Ki value of 60.3 nM. Moreover, Solithromycin exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells and Vero cells and shows a 19.47% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM concentration. It also shows moderate inhibition of the human HDAC6 enzyme, with inhibition percentages of 17.24% and 8.49% using different peptide substrates. These diverse bioactivities highlight Solithromycin as a promising candidate for further therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Solithromycin (OP-1068) is an orally bioavailable antimicrobial agent that inhibits cell viability, protein synthesis, and growth rate of Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus, and Haemophilus influenzae with IC50 values of 7.5 ng/mL, 40 ng/mL, and 125 ng/mL, respectively.Solithromycin inhibits protein biosynthesis by binding to the large 50S subunit of the ribosome.
Targets&IC50	Streptococcus pneumoniae:7.5 ng/ml, Haemophilus influenzae:125 ng/ml, S. aureus:40 ng/ml
Synonyms	OP-1068, CEM-101

Chemical Properties

Molecular Weight	845.01
Formula	C₄₃H₆₅FN₆O₁₀
Cas No.	760981-83-7
Smiles	CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cc(nn3)-c3cccc(N)c3)C(=O)O[C@]12C)OC
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (59.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1834 mL	5.9171 mL	11.8342 mL	59.1709 mL
5 mM	0.2367 mL	1.1834 mL	2.3668 mL	11.8342 mL
10 mM	0.1183 mL	0.5917 mL	1.1834 mL	5.9171 mL
20 mM	0.0592 mL	0.2959 mL	0.5917 mL	2.9585 mL
50 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1834 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc