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FKBP4 Protein, Human, Recombinant (His)

Catalog No. TMPJ-01076
Synonyms: FKBP4, HSP-binding immunophilin, immunophilin FKBP52, FK506-binding protein 4, FKBP59, Rotamase, 59kDa immunophilin, 51kDa FK506-binding protein, Peptidyl-prolyl cis-trans isomerase FKBP4

FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.

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FKBP4 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 53.00
50 μg 5 days $ 129.00
500 μg 5 days $ 1,390.00
1 mg 5 days $ 1,980.00
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Biological Description
Technical Params
Product Properties
Description FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
Species Human
Expression System E. coli
Tag C-6His
Accession Number Q02790
Synonyms FKBP4, HSP-binding immunophilin, immunophilin FKBP52, FK506-binding protein 4, FKBP59, Rotamase, 59kDa immunophilin, 51kDa FK506-binding protein, Peptidyl-prolyl cis-trans isomerase FKBP4
Amino Acid Met1-Ala459
Construction Recombinant Human 52 kDa FK506 Binding Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala459 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 50-60 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, pH 8.0.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.

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Keywords

FKBP4 Protein, Human, Recombinant (His) FKBP-59 FKBP4 HSP-binding immunophilin immunophilin FKBP52 FKBP 59 FK506-binding protein 4 FKBP-4 FKBP59 Rotamase FKBP 4 59kDa immunophilin 51kDa FK506-binding protein Peptidyl-prolyl cis-trans isomerase FKBP4 recombinant recombinant-proteins proteins protein

 

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