FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 53.00 | |
50 μg | 5 days | $ 129.00 | |
500 μg | 5 days | $ 1,390.00 | |
1 mg | 5 days | $ 1,980.00 |
Description | FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
Species | Human |
Expression System | E. coli |
Tag | C-6His |
Accession Number | Q02790 |
Synonyms | FKBP4, HSP-binding immunophilin, immunophilin FKBP52, FK506-binding protein 4, FKBP59, Rotamase, 59kDa immunophilin, 51kDa FK506-binding protein, Peptidyl-prolyl cis-trans isomerase FKBP4 |
Amino Acid | Met1-Ala459 |
Construction | Recombinant Human 52 kDa FK506 Binding Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala459 is expressed with a 6His tag at the C-terminus. |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
Molecular Weight | 50-60 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, pH 8.0. |
Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Shipping |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Research Background | FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
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FKBP4 Protein, Human, Recombinant (His) FKBP-59 FKBP4 HSP-binding immunophilin immunophilin FKBP52 FKBP 59 FK506-binding protein 4 FKBP-4 FKBP59 Rotamase FKBP 4 59kDa immunophilin 51kDa FK506-binding protein Peptidyl-prolyl cis-trans isomerase FKBP4 recombinant recombinant-proteins proteins protein