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Synonyms: pp36, p-LAT (Y191), p-LAT (Tyr191), Phospho-LAT (Y191), p36-38, Linker for activation of T-cells family member 1, LAT (p-Y191), LAT (p-Tyr191), 36 kDa phospho-tyrosine adapter protein
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
| Description | Anti-Phospho-LAT (Tyr191) Antibody (7X750) is an antibody targeting Phospho-LAT (Tyr191). Anti-Phospho-LAT (Tyr191) Antibody (7X750) can be used in ELISA,IF,IHC,IP,WB. |
| Synonyms | pp36, p-LAT (Y191), p-LAT (Tyr191), Phospho-LAT (Y191), p36-38, Linker for activation of T-cells family member 1, LAT (p-Y191), LAT (p-Tyr191), 36 kDa phospho-tyrosine adapter protein |
| Ig Type | Rabbit IgG |
| Clone | 7X750 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200; IF:1:20-1:200; IP:1:200-1:1000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. |
| Tissue Specificity | Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-LAT (Y191) |
| Antigen Species | Human |
| Gene Name | LAT |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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