Shopping Cart
- Remove All
Your shopping cart is currently empty
Mizoribine
🥰Excellent
Catalog No. T1188Cas No. 50924-49-7
Alias NSC 289637, HE 69, Bredinin
Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
Mizoribine
🥰Excellent
Purity: 99.95%
Catalog No. T1188Alias NSC 289637, HE 69, BredininCas No. 50924-49-7
Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $44 | In Stock | |
| 25 mg | $61 | In Stock | |
| 50 mg | $89 | In Stock | |
| 100 mg | $123 | In Stock | |
| 500 mg | $297 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Purity:99.95%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. |
| Targets&IC50 | Immunosuppressive:100 μM |
| In vitro | Mizoribine selectively inhibits guanine ribonucleotide synthesis in purified T-cells, while the mechanism of 6-thioguanine (6MP) appears to rely more on the depletion of adenine ribonucleotides. In a dose-dependent manner, Mizoribine at 1-50 mg/mL suppresses T-cell proliferation induced by all tested stimuli by 10-100%. This suppression is reversible with the addition of guanosine to replenish the guanine nucleotide pool when 50 mM is incorporated. Furthermore, Mizoribine impedes HCV RNA replication with an IC50 of 100 μM and causes a reduction in intracellular GTP levels, with GTP supplementation reversing its antiproliferative effect. |
| In vivo | Administration of 5 or 10 mg/kg Mizoribine resulted in increased expression of MCP-1, OPN, and TGF-β1 mRNA in untreated OLETF rats. Simultaneously, this dose of Mizoribine inhibited urinary albumin excretion and attenuated the progression of glomerulosclerosis, renal interstitial fibrosis, and macrophage infiltration in the rat kidneys. |
| Synonyms | NSC 289637, HE 69, Bredinin |
| Molecular Weight | 259.22 |
| Formula | C9H13N3O6 |
| Cas No. | 50924-49-7 |
| Smiles | O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(O)=C(C(N)=O)N=C2 |
| Relative Density. | 1.4155 g/cm3 (Estimated) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (231.46 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 47 mg/mL (181.31 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Mizoribine | purchase Mizoribine | Mizoribine cost | order Mizoribine | Mizoribine chemical structure | Mizoribine in vivo | Mizoribine in vitro | Mizoribine formula | Mizoribine molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.