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Coumermycin A1

Name: Coumermycin A1
Brand: TargetMol
SKU: T36106
Rating: 4.5 (1 reviews)

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Catalog No. T36106Cas No. 4434-05-3

Coumermycin A1, a JAK2 signal activator, inhibits DNA Gyrase, consequently impeding bacterial cell division.

Coumermycin A1

😃Good

Catalog No. T36106Cas No. 4434-05-3

Coumermycin A1, a JAK2 signal activator, inhibits DNA Gyrase, consequently impeding bacterial cell division.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description	Coumermycin A1, a JAK2 signal activator, inhibits DNA Gyrase, consequently impeding bacterial cell division.
In vitro	Coumermycin A1-induced activation of the JAK2 signaling pathway elevates SCOS2 mRNA levels while decreasing the mRNA level of the leptin receptor[1].

Chemical Properties

Molecular Weight	1110.092
Formula	C₅₅H₅₉N₅O₂₀
Cas No.	4434-05-3
Smiles	CO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4c[nH]c(C(=O)Nc5c(O)c6ccc(O[C@@H]7OC(C)(C)[C@H](OC)[C@@H](OC(=O)c8ccc(C)[nH]8)[C@H]7O)c(C)c6oc5=O)c4C)c(=O)oc3c2C)OC1(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (45.04 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9008 mL	4.5041 mL	9.0083 mL	45.0413 mL
5 mM	0.1802 mL	0.9008 mL	1.8017 mL	9.0083 mL
10 mM	0.0901 mL	0.4504 mL	0.9008 mL	4.5041 mL
20 mM	0.0450 mL	0.2252 mL	0.4504 mL	2.2521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc