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Indotecan
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Catalog No. T15578Cas No. 915303-09-2
Alias NSC-724998, LMP-400
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
Indotecan
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Purity: 98%
Catalog No. T15578Alias NSC-724998, LMP-400Cas No. 915303-09-2
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $64 | - | In Stock | |
| 5 mg | $128 | - | In Stock | |
| 10 mg | $208 | - | In Stock | |
| 25 mg | $372 | - | In Stock | |
| 50 mg | $589 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98%
Appearance:Solid
Color:Yellow to Black
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Product Introduction
Indotecan AI Summary
Indotecan exhibits potent cytotoxicity and antiproliferative activity against various human cancer cell lines, with GI50 values ranging from 30.0 nM to 74100.0 nM. Particularly, it demonstrates strong cytotoxic effects against SF539 and UACC62 cells with GI50 values of 40.0 nM and 30.0 nM respectively. Additionally, it effectively inhibits the growth of other cancer cell lines such as OVCAR-3, HOP62, HCT116, SN12C, DU145, MDA-MB-435, and MCF7. Indotecan also shows significant inhibition of recombinant human TOP1-mediated DNA cleavage, displaying 100.0% activity compared to camptothecin. Beyond its anticancer potential, it exhibits antileishmanial activity against Leishmania infantum promastigotes BCN150 with an IC50 value of 100.0 nM. These properties suggest that Indotecan could be a promising candidate for further exploration as a therapeutic agent in cancer and infectious disease treatments..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively). |
| Targets&IC50 | Topo I:1200nM(HCT116 cell lines) , Topo I:300nM(P388 ), Topo I:560 nM (MCF-7 cell lines ) |
| Synonyms | NSC-724998, LMP-400 |
| Molecular Weight | 478.49 |
| Formula | C26H26N2O7 |
| Cas No. | 915303-09-2 |
| Smiles | COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCN3CCOCC3)c(=O)c2cc1OC |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Insoluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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