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Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody
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Catalog No. TMAC-00614
Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr670). Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody can be used in WB.
Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody
Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody
😃Good
Catalog No. TMAC-00614
Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr670). Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $217 | 7-10 days | |
| 100 μL | $316 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr670). Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-3000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 670 (Q-W-Y(p)-K-K) derived from Human CTNNB1 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 85 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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