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Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody

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Catalog No. TMAC-00614

Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr670). Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody can be used in WB.

Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody

Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody

😃Good
Catalog No. TMAC-00614
Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr670). Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody can be used in WB.
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50 μL$2177-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CTNNB1 (Tyr670). Anti-Phospho-CTNNB1 (Tyr670) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-3000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundKey downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of tyrosine 670 (Q-W-Y(p)-K-K) derived from Human CTNNB1
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 85 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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