Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 93.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 455.00 | |
100 mg | In stock | $ 672.00 | |
500 mg | In stock | $ 1,380.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 90.00 |
Description | 5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK. |
In vitro | Estrogen receptor positive (ER+; MCF-7 and T47D) breast cancer cells, estrogen receptor negative (ER?; CRL2335, MDA-MB-231, and MDA-MB-468) breast cancer cells, and nonmalignant MCF-10A cells are treated with 5F 203 or vehicle control (0.1% DMSO) for 72 h. Nonmalignant MCF-10A breast epithelial cells and MDA-MB-231 breast cancer cells were resistant to 5F 203 treatment, whereas the other cell lines showed varying sensitivity to 5F 203. |
Synonyms | 5F-203, NSC-703786 |
Molecular Weight | 258.31 |
Formula | C14H11FN2S |
CAS No. | 260443-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (96.78 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
5-fluoro 203 260443-89-8 Others AhR 5fluoro 203 5F 203 Aryl Hydrocarbon Receptor 5 fluoro 203 NSC 703786 inhibit 5F-203 NSC-703786 5F203 NSC703786 Inhibitor inhibitor