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Balsalazide disodium dihydrate

Name: Balsalazide disodium dihydrate
Brand: TargetMol
SKU: T4615
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4615 Copy Product Info

Purity: 99.49%

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Balsalazide disodium dihydrate is an aminosalicylate prodrug that releases mesalazine (HY-15027) in the colon. It also exerts anti-inflammatory and anti-cancer effects by modulating the IL-6/STAT3 pathway, and is used in the research of inflammatory bowel disease and cancer.

Cas No. 150399-21-6

Pack Size	Price	USA Stock	Global Stock
5 mg	$39	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$105	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$239	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.49%

Appearance:Solid

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Balsalazide disodium dihydrate is an aminosalicylate prodrug that releases mesalazine (HY-15027) in the colon. It also exerts anti-inflammatory and anti-cancer effects by modulating the IL-6/STAT3 pathway, and is used in the research of inflammatory bowel disease and cancer.
In vitro	Methods: The FLUOR DE LYS® Sirt5 Fluorometric Drug Discovery Assay Kit was used. Sirt5 enzyme was incubated with 50 μM Balsalazide disodium dihydrate for 1 hour to determine its inhibitory activity. Results: Balsalazide disodium dihydrate inhibited 89% of Sirt5 activity at 50 μM concentration, with an IC₅₀ value of 13.8 μM. [1] Methods: 10% rat feces, cecal, and colonic contents bioreactors were used, and drugs were anaerobically incubated at 500 μM for 240 minutes to determine degradation kinetics. Results :The degradation rate constant of balsalazide in rat feces was 0.015 min⁻¹, which was relatively close to human data (0.009 min⁻¹). [2]
In vivo	Methods:In an AOM/DSS-induced colitis-associated colorectal cancer (CAC) mouse model, Balsalazide disodium dihydrate was administered orally by gavage at a dose of 200 mg/kg once daily (dissolved in normal saline) for three cycles. Results: The combination treatment group showed recovery of body weight, improvement in colon shortening, and significant reduction in histological inflammation and infiltration depth scores. [3]

Chemical Properties

Molecular Weight	437.31
Formula	C₁₇H₁₇N₃Na₂O₈
Cas No.	150399-21-6
Smiles	[Na+].[Na+].O.O.O=C([O-])c1cc(ccc1O)/N=N/c2ccc(cc2)C(=O)NCCC([O-])=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 168.3 mg/mL (384.85 mM), Sonication is recommended.

H2O: 198.9 mM, Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2867 mL	11.4335 mL	22.8671 mL	114.3354 mL
5 mM	0.4573 mL	2.2867 mL	4.5734 mL	22.8671 mL
10 mM	0.2287 mL	1.1434 mL	2.2867 mL	11.4335 mL
20 mM	0.1143 mL	0.5717 mL	1.1434 mL	5.7168 mL
50 mM	0.0457 mL	0.2287 mL	0.4573 mL	2.2867 mL
100 mM	0.0229 mL	0.1143 mL	0.2287 mL	1.1434 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

STATInterleukinBalsalazide sodiumBalsalazide

Related Tags: Balsalazide disodium dihydrate chemical structure | Balsalazide disodium dihydrate in vivo | Balsalazide disodium dihydrate in vitro | Balsalazide disodium dihydrate formula | Balsalazide disodium dihydrate molecular weight