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Coumarins

Coumarins (1-benzopyran-2-one) are chemical compounds in the benzopyrone class of organic compounds found in many plants. Coumarins possess a variety of biological properties, including antimicrobial, antiviral, antiinflammatory, antidiabetic, antioxidant, and enzyme inhibitory activity.

  • 4-Ethoxycoumarin
    Fr1266235817-27-7
    4-Ethoxycoumarin has antimicrobial activity.
    • $60
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  • 4-Methoxycoumarine
    Fr1229020280-81-3
    4-Methoxycoumarine has antitumour effects.
    • $10
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  • 3-Acetylcoumarin
    Fr125963949-36-8
    3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.
    • $29
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  • 4-Hydroxy-6-methylcoumarin
    Fr1227713252-83-0
    4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.
    • $60
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  • 4-Methylesculetin
    TJS0338529-84-0
    4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
    • $30
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  • 4-Methyl-6-Methoxycoumarin
    T81136295-35-8
    4-Methyl-6-Methoxycoumarin is a natural product isolated from Eupatorium pauciflorum.
    • $50
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  • Bergaptol
    T2S1434486-60-2
    1. Bergaptol (4-Hydroxybergapten) shows very good radical scavenging activity. 2. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.
    • $29
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  • Herniarin
    T7049531-59-9
    Herniarin (Ayapanin) is a natural coumarin with antitumor effect.
    • $42
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  • Triumbelletin
    TMA2253131559-54-1
    Triumbelletin is a tricoumarin rhamnopyranoside obtained from Wikstroemia indica with antitumour activity for the study of tumours.
    • $479
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  • 8-Acetyl-7-Hydroxycoumarin
    T79936748-68-1
    8-Acetyl-7-Hydroxycoumarin is a natural compound,with Antifungal and antibacterial activities
    • $54
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  • 5-Geranoxy-7-methoxycoumarin
    TN31107380-39-4
    5-Geranoxy-7-methoxycoumarin shows antifungal activity.
    • $106
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  • Novobiocin
    T20510303-81-1
    Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections.
    • $30
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  • Vinaxanthone
    T70955133293-89-7In house
    Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that is a selective and potent semaphorin3A, phospholipase C (PLC), and FabI inhibitor, inhibiting semaphorin3A and FabI.Vinaxanthone exhibits antimicrobial activity, blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.
    • $639
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  • Coumarin 6
    TN152938215-36-0
    Coumarin 6 (Coumarin VI) is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.
    • $47
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  • 6-Methylcoumarin
    T564792-48-8
    6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.
    • $42
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  • Br-Mmc
    T1892735231-44-8
    Br-Mmc (4-Bromomethyl-7-methoxycoumarin) is used as a new fluorescence label for fatty acids. It is used for the determination of fatty acids by HPLC or TLC.
    • $29
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  • 4-Methyldaphnetin
    TJS03152107-77-9
    4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin(7,8-Dihydroxy-4-methylcoumarin) inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.
    • $30
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  • 6-Hydroxycoumarin
    T2S03576093-68-1
    6-Hydroxycoumarin (6-hydroxychromen-2-one) exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a human CA9, CA12 inhibitor.
    • $29
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  • 5,7-Dihydroxy-4-methylcoumarin
    TJS03142107-76-8
    5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) inhibits human neutrophil oxidative metabolism and elastase activity. 5,7-Dihydroxy-4-methylcoumarin has in vitro platelet antiaggregatory property. 5,7-Dihydroxy-4-methylcoumarin shows inhibition of the cyclooxygenase pathway.
    • $42
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  • Glycycoumarin
    TN170294805-82-0
    Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
    • $74
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  • Hydrangetin
    TN4236485-90-5
    Hydrangetin (7-Hydroxy-8-methoxycoumarin) is a small molecule compound from Daphne papyracea var that inhibits platelet aggregation.
    • $812
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  • 7-Prenyloxycoumarin
    T574410387-50-5
    7-Prenyloxycoumarin (Nsc267697) is a natural product from Heracleum dissectum,and possess preventive and therapeutic effects on breast cancer but they have also cytotoxic effects on some other cancer cell lines.
    • $34
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  • Sparstolonin B
    T382611259330-61-4
    Sparstolonin B, a selective TLR2 and TLR4 antagonist, is an isocoumarin compound isolated from the tubers of Sparganium stoloniferum and Scirpus yagara with anti-HIV, anticancer, antitumour and anti-inflammatory activities, inhibits selective Toll-like receptors, inhibits free fatty acids It inhibits selective Toll-like receptors, inhibits free fatty acid palmitate-induced chondrocyte inflammation and attenuates post-traumatic arthritis in obese mice, and inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes, which can be used for validation and mammary carcinoma studies.
    • $97
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  • 7-Ethoxycoumarin
    T797031005-02-4
    7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1.
    • $48
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  • Ethyl 3-coumarincarboxylate
    TJS03111846-76-0
    Ethyl coumarin-3-carboxylate, a coumarin derivative, serves as a pseudo-template for the synthesis of Molecularly Imprinted Polymers (MIPs) that specifically recognize aflatoxins.
    • $29
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  • Cnidilin
    TN104814348-22-2
    Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.
    • $117
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  • Nordalbergin
    TJS0328482-82-6
    Nordalbergin is a coumarin isolated from the bark of Dalbergia sissoo. It significantly induces differentiation of HL-60 cells.
    • $60
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  • LC3-mHTT-IN-AN2
    T50707758-73-8
    LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.
    • $41
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  • 7-Amino-4-methylcoumarin-3-acetic acid
    TN1328106562-32-7
    7-Amino-4-methylcoumarin-3-acetic acid (7-Amino-4-methylcoumarin) is more suitable as a substrate for enteropeptidase than GD(4)K-NA.
    • $30
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  • 7-Methylcoumarin
    T79342445-83-2
    7-Methylcoumarin with strong hepatoprotective activity.
    • $42
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  • Casegravol
    TN360574474-76-3
    Casegravol is a new monomeric coumarin isolated from the bark of Casearia graveolens Dalz with antiproliferative activity and can be used in the study of gastric adenocarcinoma and uterine cancer.
    • $849
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  • Chalepensin
    TN362713164-03-9
    Chalepensin, a furanocoumarin isolated from the rutaceae plant Ruta chalepensis L., is a selective CYP2A6 inhibitor, inhibiting CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4.Chalepensin exhibits Chalepensin j has antiprotozoal activity and inhibits methicillin-resistant Staphylococcus aureus (MRSA) with MIC values in the range of 32-128 μg/mL.
    • $1,658
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  • 3-Cyano-7-ethoxycoumarin
    T7696117620-77-6
    3-Cyano-7-ethoxycoumarin is cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 .
    • $50
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  • Magnolioside
    TN190520186-29-2
    Magnolioside has anti-plasmodial activity, shows notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum. It also shows a moderate antibacterial activity against Staphylococcus aureus CIP 53.154.Magnolioside exhibits significant neuroprotective activities against glutamate-induced toxicity.
    • $89
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  • 7-Amino-4-(trifluoromethyl)coumarin
    TJS034153518-15-3
    7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 (GALR2) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a galanin receptor 2 (GalR2) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 inhibitor with the activity value of 21 uM.
    • $57
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  • 3-Hydroxycoumarin
    T8002939-19-5
    3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors
    • $50
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  • 7-Ethoxy-4-Methylcoumarin
    T803887-05-8
    7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body.
    • $29
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  • Coumarin-3-carboxylic acid
    TJS0339531-81-7
    The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/VEGFR2/c-Met-Akt-NF-κB signaling pathways; this combination may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of lung cancer.
    • $48
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  • 4-Phenyl-7,8-dihydroxycoumarin
    TJS0368842-01-3
    4-Phenyl-7,8-dihydroxycoumarin (7,8-Dihydroxy-4-phenylcoumarin) inhibits the activity of Staphylococcus aureus DNA helicase
    • $38
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  • Scopoletin acetate
    TN218956795-51-8
    Scopoletin acetate (7-Acetoxy-6-methoxycoumari) is a coumarin analog derived from Artemisia granatensis with antioxidant, antimicrobial, cardioprotective and anticancer activities.
    • $498
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