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Anti-CD71 Monoclonal Antibody
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Catalog No. TMAZ-0133
Alias Transferrin receptor protein 1, T9, p90
Anti-CD71 Monoclonal Antibody is a humanized rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody can be used in ELISA,FCM.
Anti-CD71 Monoclonal Antibody
Anti-CD71 Monoclonal Antibody
😃Good
Catalog No. TMAZ-0133Alias Transferrin receptor protein 1, T9, p90
Anti-CD71 Monoclonal Antibody is a humanized rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody can be used in ELISA,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μg | $120 | 12 days | 12 days | |
| 50 μg | $143 | 12 days | 12 days | |
| 100 μg | $201 | 12 days | 12 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Concentration:0.71 mg/mL
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD71 Monoclonal Antibody is a humanized rabbit antibody targeting CD71. Anti-CD71 Monoclonal Antibody can be used in ELISA,FCM. |
| Synonyms | Transferrin receptor protein 1, T9, p90 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of Jurkat cells with TMAZ-0133BI, followed by goat anti-rabbit IgG-ABflo 647 (red). The isotype control is rabbit IgG (black line). |
| Application | |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD71 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed: 26214738). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed: 26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed: 26214738). When dietary levels of stearate (C18: 0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed: 26214738). When dietary levels of stearate (C18: 0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed: 26214738)|(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus |
| Conjucates | Unconjugated |
| Others Formats | Biotin |
| Antibody Types Available | 2 |
| Immunogen | CD71 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer Research |
| Molecular Weight | 150 kDa |
| Color | Transparent |
| Appearance | Liquid |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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