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SW155246

Name: SW155246
Brand: TargetMol
SKU: T8967
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8967Cas No. 420092-79-1

SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

SW155246

🥰Excellent

Purity: 98.99%

Catalog No. T8967Cas No. 420092-79-1

SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$68	In Stock
25 mg	$142	In Stock
50 mg	$226	In Stock
100 mg	$358	In Stock
500 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock

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Batch Information

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Purity:98.99%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
Targets&IC50	DNMT1:1.2 μM

Chemical Properties

Molecular Weight	378.79
Formula	C₁₆H₁₁ClN₂O₅S
Cas No.	420092-79-1
Smiles	Oc1ccc(NS(=O)(=O)c2ccc(Cl)c(c2)[N+]([O-])=O)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (132 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6400 mL	13.1999 mL	26.3999 mL	131.9993 mL
5 mM	0.5280 mL	2.6400 mL	5.2800 mL	26.3999 mL
10 mM	0.2640 mL	1.3200 mL	2.6400 mL	13.1999 mL
20 mM	0.1320 mL	0.6600 mL	1.3200 mL	6.6000 mL
50 mM	0.0528 mL	0.2640 mL	0.5280 mL	2.6400 mL
100 mM	0.0264 mL	0.1320 mL	0.2640 mL	1.3200 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc