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SW155246

Name: SW155246
Brand: TargetMol
SKU: T8967
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8967Cas No. 420092-79-1

SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

SW155246

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Purity: 98.99%

Catalog No. T8967Cas No. 420092-79-1

SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	-	In Stock
10 mg	$68	-	In Stock
25 mg	$142	-	In Stock
50 mg	$226	-	In Stock
100 mg	$358	-	In Stock
500 mg	$768	-	In Stock
1 mL x 10 mM (in DMSO)	$42	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.99%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

SW155246 AI Summary

SW155246 exhibits bioactivity as an inhibitor of DNA methyltransferase enzymes DNMT3a and DNMT1. For DNMT3a, the compound showed an IC50 of 38000.0 nM, indicating moderate inhibitory activity. Meanwhile, for DNMT1, the compound demonstrated a lower IC50 of 12000.0 nM, suggesting more potent inhibition of this enzyme. The bioactivity of this compound highlights its potential as a DNA methyltransferase inhibitor in cellular processes related to DNA methylation regulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.
Targets&IC50	DNMT1:1.2 μM

Chemical Properties

Molecular Weight	378.79
Formula	C₁₆H₁₁ClN₂O₅S
Cas No.	420092-79-1
Smiles	Oc1ccc(NS(=O)(=O)c2ccc(Cl)c(c2)[N+]([O-])=O)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (132 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6400 mL	13.1999 mL	26.3999 mL	131.9993 mL
5 mM	0.5280 mL	2.6400 mL	5.2800 mL	26.3999 mL
10 mM	0.2640 mL	1.3200 mL	2.6400 mL	13.1999 mL
20 mM	0.1320 mL	0.6600 mL	1.3200 mL	6.6000 mL
50 mM	0.0528 mL	0.2640 mL	0.5280 mL	2.6400 mL
100 mM	0.0264 mL	0.1320 mL	0.2640 mL	1.3200 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc