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NecroX-5

🥰Excellent
Catalog No. T12204Cas No. 1383718-29-3

NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.

NecroX-5

NecroX-5

🥰Excellent
Purity: 99.944%
Catalog No. T12204Cas No. 1383718-29-3
NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$46In StockIn Stock
2 mg$67In StockIn Stock
5 mg$113In StockIn Stock
10 mg$163In StockIn Stock
25 mg$262In StockIn Stock
50 mg$371In StockIn Stock
100 mgPreferentialIn StockIn Stock
1 mL x 10 mM (in DMSO)$161In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.944%
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Product Introduction

Bioactivity
Description
NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.
In vitro
NecroX-5 (10-40 μM) reduces mitochondrial ROS levels and inhibits AKT and breast cancer cell migration. NecroX-5 (10 μM) blocks Ca2+ influx and decreases intracellular calcium concentration in 4T1 cells[1]. In LPS-stimulated H9C2 cells, NecroX-5 (10 µM), effectively decreases the increased TGF-β1, pSmad2, TNF-α and the expression of Dcn[2].
In vivo
In TUBO-P2J tumour-bearing mice, NecroX-5 (2.5 mg/kg) inhibits the metastasis of breast cancer cell[1].
Chemical Properties
Molecular Weight645.81
FormulaC27H39N3O9S3
Cas No.1383718-29-3
SmilesCS(O)(=O)=O.CS(O)(=O)=O.O=S1(=O)CCN(Cc2cc(NCC3CCOCC3)c3[nH]c(cc3c2)-c2ccccc2)CC1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 153.0 mg/mL (236.9 mM ), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.19 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5484 mL7.7422 mL15.4844 mL77.4222 mL
5 mM0.3097 mL1.5484 mL3.0969 mL15.4844 mL
10 mM0.1548 mL0.7742 mL1.5484 mL7.7422 mL
20 mM0.0774 mL0.3871 mL0.7742 mL3.8711 mL
50 mM0.0310 mL0.1548 mL0.3097 mL1.5484 mL
100 mM0.0155 mL0.0774 mL0.1548 mL0.7742 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NecroX-5NecroX5NecroX 5CalciumChannelCalcium ChannelCalcium channel
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