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NecroX-5

Name: NecroX-5
Brand: TargetMol
SKU: T12204
Price: 371 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12204Cas No. 1383718-29-3

NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.

NecroX-5

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Purity: 99.94%

Catalog No. T12204Cas No. 1383718-29-3

NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
2 mg	$67	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$262	In Stock	In Stock
50 mg	$371	In Stock	In Stock
100 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$161	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.
In vitro	NecroX-5 (10-40 μM) reduces mitochondrial ROS levels and inhibits AKT and breast cancer cell migration. NecroX-5 (10 μM) blocks Ca2+ influx and decreases intracellular calcium concentration in 4T1 cells[1]. In LPS-stimulated H9C2 cells, NecroX-5 (10 µM), effectively decreases the increased TGF-β1, pSmad2, TNF-α and the expression of Dcn[2].
In vivo	In TUBO-P2J tumour-bearing mice, NecroX-5 (2.5 mg/kg) inhibits the metastasis of breast cancer cell[1].

Chemical Properties

Molecular Weight	645.81
Formula	C₂₇H₃₉N₃O₉S₃
Cas No.	1383718-29-3
Smiles	CS(O)(=O)=O.CS(O)(=O)=O.O=S1(=O)CCN(Cc2cc(NCC3CCOCC3)c3[nH]c(cc3c2)-c2ccccc2)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 153 mg/mL (236.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5484 mL	7.7422 mL	15.4844 mL	77.4222 mL
5 mM	0.3097 mL	1.5484 mL	3.0969 mL	15.4844 mL
10 mM	0.1548 mL	0.7742 mL	1.5484 mL	7.7422 mL
20 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8711 mL
50 mM	0.0310 mL	0.1548 mL	0.3097 mL	1.5484 mL
100 mM	0.0155 mL	0.0774 mL	0.1548 mL	0.7742 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc