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HIV-1 inhibitor-25

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Catalog No. T62431Cas No. 2475658-74-1

HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) with an IC50 of 0.1061 nM. It exhibits a high antiviral effect against wild-type HIV-1 (EC50: 13.6 nM) and demonstrates low cytotoxicity (to MT). It also inhibits HIV-1 mutants (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A) with EC50 values ranging from 0.1961 to 5.8136 μM. HIV-1 inhibitor-25 is useful for studying AIDS.

HIV-1 inhibitor-25

HIV-1 inhibitor-25

😃Good
Catalog No. T62431Cas No. 2475658-74-1
HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) with an IC50 of 0.1061 nM. It exhibits a high antiviral effect against wild-type HIV-1 (EC50: 13.6 nM) and demonstrates low cytotoxicity (to MT). It also inhibits HIV-1 mutants (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A) with EC50 values ranging from 0.1961 to 5.8136 μM. HIV-1 inhibitor-25 is useful for studying AIDS.
Pack SizePriceAvailabilityQuantity
25 mg$2,140 6-8 weeks
50 mg$2,785 6-8 weeks
100 mg$3,520 6-8 weeks
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Product Introduction

Bioactivity
Description
HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) with an IC50 of 0.1061 nM. It exhibits a high antiviral effect against wild-type HIV-1 (EC50: 13.6 nM) and demonstrates low cytotoxicity (to MT). It also inhibits HIV-1 mutants (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A) with EC50 values ranging from 0.1961 to 5.8136 μM. HIV-1 inhibitor-25 is useful for studying AIDS.
Targets&IC50
HIV-1 (F227L+V106A):3.0683 ± 0 μM (EC50), E138K:0.1961 ± 0 μM (EC50), Y181C:0.5075 μM (EC50), HIV IIIB:13.6 nM (EC50), L100I:1.2458 μM (EC50), Y188L:5.8136 ± 2 μM (EC50), K103N:0.4383 (EC50)
Chemical Properties
Molecular Weight433.46
FormulaC26H19N5O2
Cas No.2475658-74-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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