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Anti-Prolactin Receptor Antibody-HRP (8B416)

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Catalog No. TMAY-00549H
Alias prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712

Anti-Prolactin Receptor Antibody-HRP (8B416) is a HRP-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-HRP (8B416) can be used in ELISA.

Anti-Prolactin Receptor Antibody-HRP (8B416)

Anti-Prolactin Receptor Antibody-HRP (8B416)

😃Good
Catalog No. TMAY-00549HAlias prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712
Anti-Prolactin Receptor Antibody-HRP (8B416) is a HRP-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-HRP (8B416) can be used in ELISA.
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100 μg$411 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Prolactin Receptor Antibody-HRP (8B416) is a HRP-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-HRP (8B416) can be used in ELISA.
Aliasprolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712
Ig Type
Monoclonal Rabbit IgG
Clone
8B416
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 0.1-1 μg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human PRLR (rh PRLR; TMPY-01053; NP_000940.1; Met 1-Asp 234), and conjugated with horseradish-peroxidase (HRP).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundProlactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.
Related Conjugates and Formulations
Conjucates
HRP
Others Formats
Unconjugated/APC/PE
Antibody Types Available
4
Antigen Details
Immunogen
Recombinant Human PRLR protein (TMPY-01053)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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