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Anti-Prolactin Receptor Antibody-HRP (8B416)
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Catalog No. TMAY-00549H
Alias prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712
Anti-Prolactin Receptor Antibody-HRP (8B416) is a HRP-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-HRP (8B416) can be used in ELISA.
Anti-Prolactin Receptor Antibody-HRP (8B416)
Anti-Prolactin Receptor Antibody-HRP (8B416)
😃Good
Catalog No. TMAY-00549HAlias prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712
Anti-Prolactin Receptor Antibody-HRP (8B416) is a HRP-conjugated Rabbit antibody targeting Prolactin Receptor. Anti-Prolactin Receptor Antibody-HRP (8B416) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $411 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | prolactin receptor, Prlr-rs1, Prlr, Pr-3, Pr-1, AI987712 |
| Ig Type | Rabbit IgG |
| Clone | 8B416 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 0.1-1 μg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human PRLR (rh PRLR; TMPY-01053; NP_000940.1; Met 1-Asp 234), and conjugated with horseradish-peroxidase (HRP). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules involved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer. |
| Conjucates | HRP |
| Others Formats | Unconjugated/APC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human PRLR protein (TMPY-01053) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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