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Olmutinib

Name: Olmutinib
Brand: TargetMol
SKU: T6918
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6918Cas No. 1353550-13-6

Alias HM61713, BI 1482694, HM61713, BI 1482694, 1802181-20-9

Olmutinib (HM61713, BI 1482694) is an orally available small molecule, a mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Olmutinib binds to and inhibits mutant forms of EGFR, thereby leading to cell death of EGFR-expressing tumor cells. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR inhibitors which also inhibit the EGFR wild-type form.

Olmutinib

🥰Excellent

Purity: 99.63%

Catalog No. T6918Alias HM61713, BI 1482694, HM61713, BI 1482694, 1802181-20-9Cas No. 1353550-13-6

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$189	In Stock	In Stock
100 mg	$297	In Stock	In Stock
200 mg	$486	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Olmutinib (HM61713, BI 1482694) is an orally available small molecule, a mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Olmutinib binds to and inhibits mutant forms of EGFR, thereby leading to cell death of EGFR-expressing tumor cells. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR inhibitors which also inhibit the EGFR wild-type form.
Targets&IC50	BTK:13.9 nM, EGFR L858R/T790M:10 nM (cell assay), EGFR (exon 19 deletion):9.2 nM (cell assay)
In vitro	HM61713 causes potent inhibition in cell lines H1975 (L858R and T790M) and HCC827 (exon 19 deletion). It has a low potency for NSCLC cell line H358 harboring wild-type EGFR (GI50 of 2225 nM)[1].
In vivo	HM61713 has a half-life of over 24 h for EGFR inhibition. In the in vivo studies of xenograft models with grafts of H1975 and HCC827, HM61713 is active against the tumors without showing any side effects[1].
Synonyms	HM61713, BI 1482694, HM61713, BI 1482694, 1802181-20-9

Chemical Properties

Molecular Weight	486.59
Formula	C₂₆H₂₆N₆O₂S
Cas No.	1353550-13-6
Smiles	CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3sccc3n2)cc1
Relative Density.	1.336 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 22 mg/mL (45.21 mM), Sonication is recommended.

DMSO: 90 mg/mL (184.96 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0551 mL	10.2756 mL	20.5512 mL	102.7559 mL
5 mM	0.4110 mL	2.0551 mL	4.1102 mL	20.5512 mL
10 mM	0.2055 mL	1.0276 mL	2.0551 mL	10.2756 mL
20 mM	0.1028 mL	0.5138 mL	1.0276 mL	5.1378 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0551 mL
100 mM	0.0206 mL	0.1028 mL	0.2055 mL	1.0276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc